Nanomechanical Phenotype of Melanoma Cells Depends Solely on the Amount of Endogenous Pigment in the Cells

International Journal of Molecular Sciences
Michal SarnaKrystyna Urbanska

Abstract

Cancer cells have unique nanomechanical properties, i.e., they behave as if they were elastic. This property of cancer cells is believed to be one of the main reasons for their facilitated ability to spread and metastasize. Thus, the so-called nanomechanical phenotype of cancer cells is viewed as an important indicator of the cells' metastatic behavior. One of the most highly metastatic cancer cells are melanoma cells, which have a very unusual property: they can synthesize the pigment melanin in large amounts, becoming heavily pigmented. So far, the role of melanin in melanoma remains unclear, particularly the impact of the pigment on metastatic behavior of melanoma cells. Importantly, until recently the potential mechanical role of melanin in melanoma metastasis was completely ignored. In this work, we examined melanoma cells isolated from hamster tumors containing endogenous melanin pigment. Applying an array of advanced microscopy and spectroscopy techniques, we determined that melanin is the dominating factor responsible for the mechanical properties of melanoma cells. Our results indicate that the nanomechanical phenotype of melanoma cells may be a reliable marker of the cells' metastatic behavior and point to the importa...Continue Reading

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Citations

Apr 2, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Sarah YoussefRoman Gr Maev
May 9, 2019·Scientific Reports·Katarzyna Jasińska-KoniorMartyna Elas
Apr 21, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Andrzej ŻądtoTadeusz Sarna
May 21, 2020·International Journal of Molecular Sciences·Kevin YangAndrzej T Slominski
Dec 19, 2018·International Journal of Molecular Sciences·Alessandra Napolitano, Shosuke Ito
Aug 2, 2018·International Journal of Molecular Sciences·Ewa PodgorskaKrystyna Urbanska
Jun 28, 2019·Scientific Reports·Michal SarnaKrystyna Urbanska
Jan 15, 2021·Cell Biochemistry and Biophysics·Sharareh TavaddodHossein Naderi-Manesh
Mar 18, 2021·European Biophysics Journal : EBJ·Anna SobiepanekTomasz Kobiela

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Methods Mentioned

BETA
atomic force microscopy
electron paramagnetic resonance
confocal microscopy
atomic force spectroscopy
force
AFM

Software Mentioned

AtomicJ
Mathematica

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