PMID: 19928159Nov 26, 2009Paper

Nanomechanical properties of electrospun composite scaffolds based on polycaprolactone and hydroxyapatite

Journal of Nanoscience and Nanotechnology
Parul TyagiY K Vohra

Abstract

Fibrous nanocomposite scaffolds were electrospun from dispersions of hydroxyapatite nanoparticles (nanoHA) in polycaprolactone (PCL) with varying nanoHA contents (from 0% to 50% by weight). Such scaffolds were produced to mimic the nano-features of the extracellular matrix (ECM) for natural bone tissue regeneration. NanoHA was found to be well dispersed in the PCL fibers up to the addition of 30 wt%, whereas beads and agglomeration of HA particles was observed above this nanoHA concentration. The structural and morphological characterizations were evaluated by scanning electron microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), and X-ray Diffraction (XRD). The average fiber diameter decreased with increased nanoHA concentration. The nanomechanical properties of the as-spun fibrous scaffolds as well as pressure-consolidated (pelletized) composites were evaluated by nanoindentation. Elastic modulus increased with increasing HA content, but was especially pronounced for 40-50% HA content where the indenter tip is more likely to probe agglomerated HA particles.

Citations

May 28, 2013·Journal of the Mechanical Behavior of Biomedical Materials·M KharazihaH Edris
Mar 15, 2011·Journal of the Mechanical Behavior of Biomedical Materials·Keng-Liang OuShou-Yi Chang
May 17, 2011·Journal of Nanobiotechnology·Sri D VidyalaSamir M Iqbal
Apr 8, 2020·Journal of Materials Science. Materials in Medicine·Muna M Kareem, K Elizabeth Tanner
Jan 26, 2016·Materials·Muhammad ZafarFarshid Sefat
Nov 12, 2019·Bioactive Materials·Maria P Nikolova, Murthy S Chavali

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