Nanomechanical properties of polyethylene glycol brushes on gold substrates

The Journal of Physical Chemistry. B
Gheorghe StanRobert F Cook

Abstract

A necessary step in advancing the use of polyethylene glycol (PEG) surface coatings in critical biotechnological applications such as cancer treatments is to provide direct and reliable nanoscale property characterization. Measurements for such characterization are currently provided by scanning probe methods, which are capable of assessing heterogeneity of both surface coverage and properties with nanoscale spatial resolution. In particular, atomic force microscopy (AFM) can be used to detect and quantify the heterogeneity of surface coverage, whereas atomic force spectroscopy can be used to determine mechanical properties, thereby revealing possible heterogeneity of properties within coatings. In this work, AFM and force spectroscopy were used to characterize the morphology and mechanical properties of thiol-functionalized PEG surface coatings on flat gold substrates in aqueous PEG solution. Thiol-functionalized PEG offers a direct and simple method of attachment to gold substrates without intermediate anchoring layers and therefore can be exploited in developing PEG-functionalized gold nanoparticles. AFM was used to investigate the morphology of the PEG coatings as a function of molecular weight; the commonly observed covera...Continue Reading

References

Sep 9, 1994·Science·C BustamanteS Smith
Jun 20, 1997·Chemical Reviews·Robert W. Carpick, Miquel Salmeron
Jun 13, 2002·Journal of the American Chemical Society·Yang Song, Royce W Murray
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Jul 28, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Bogdan ZdyrkoIgor Luzinov
Feb 17, 2005·Journal of the American Chemical Society·Gerd H WoehrleJames E Hutchison
Mar 23, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Jonas RundqvistDavid B Haviland
Apr 14, 2005·Nano Letters·Christopher LooRebekah Drezek
Apr 6, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Zhiyong SuoBrenda Spangler
Aug 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Takuro NiidomeYasuro Niidome
May 5, 2007·Journal of the American Chemical Society·Joseph B TracyRoyce W Murray
Jul 3, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephan T Stern, Scott E McNeil
Dec 22, 2007·Nanomedicine·Jennifer B HallScott E McNeil
Jul 5, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Ian W Hamley, Marta J Krysmann
Jul 26, 2008·Nature Nanotechnology·Marina A Dobrovolskaia, Scott E McNeil
Aug 12, 2008·Biomedical Materials·M-E Aubin-Tam, K Hamad-Schifferli
Dec 17, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Marina A DobrovolskaiaScott E McNeil
Oct 21, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Frank W DelRioRobert F Cook

❮ Previous
Next ❯

Citations

Sep 4, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Yi ZouGuangzhao Mao
Jul 28, 2018·Colloids and Surfaces. B, Biointerfaces·Bahman FarziCetin Cetinkaya
Feb 5, 2014·Biomacromolecules·Fredrick P RojasLin Han
Dec 8, 2021·Nano Letters·Jinchi HanVladimir Bulović

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.