Nanomedicine for Atherosclerosis: Molecular Imaging and Treatment

Journal of Biomedical Nanotechnology
Varvara KaragkiozakiAnna-Maria Pappa

Abstract

Cardiovascular diseases (CVDs) and the underlying process of atherosclerosis are considered to be the most frequent causes of mortality and morbidity in developed societies. Atherosclerosis constitutes a systemic, chronic and progressive inflammatory disease that is initiated by early endothelial dysfunction and is subsequently amplified by oxidative stress, lipid deposition and monocyte recruitment. An interplay occurs among diverse cells, chemoattractants, adhesion molecules and low-density lipoproteins in the subendothelium. Due to the complexity of its pathogenesis, effective therapeutic strategies have not yet been applied in routine clinical practice. With the advent of nanotechnology, nanoparticulate systems with diagnostic and therapeutic moieties for the site-specific targeting of atherosclerotic lesions as well as nanomaterials that are suitable for cardiovascular implants may offer possible solutions to certain shortfalls of current treatment regimens. This article describes the recent advances that involve different types of nanoparticles for the early detection and concurrent therapy of atherosclerotic lesions. Moreover, it provides a state-of-the-art overview of stent technology in the restoration of normal blood ...Continue Reading

Citations

Sep 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anjali Sharma, Ashok Kakkar
Jun 1, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jia ZhangShu Wang
Feb 15, 2017·Experimental Biology and Medicine·Khosrow KhodabandehlouEun Ji Chung
Dec 13, 2017·Antioxidants & Redox Signaling·Kye S KimPeter M Kang
Apr 10, 2018·Nanotechnology·Veroniki BakolaStergious Logothetidis
Dec 30, 2016·Future Science OA·Varvara KaragkiozakiStergios Logothetidis
Apr 29, 2020·International Journal of Molecular Sciences·Nataliya V MushenkovaAlexander N Orekhov
Apr 4, 2021·Pharmaceutics·Rajasekharreddy PalaSurya M Nauli
Aug 21, 2020·Biomaterials·Alina ZenychCédric Chauvierre

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