Nanomedicine for glaucoma: sustained release latanoprost offers a new therapeutic option with substantial benefits over eyedrops

Drug Delivery and Translational Research
Tina T WongSubbu S Venkatraman

Abstract

Glaucoma is a chronic progressive optic neuropathy that is characterized by optic nerve changes and visual field loss. Elevated intraocular pressure (IOP) is the main modifiable risk factor. Chronic instillation of daily eyedrops to lower IOP is the primary treatment of choice, although it requires patient adherence and correct performance. We have developed a nanoliposome drug delivery system for the longer term delivery of latanoprost. In the present open-label, pilot study, the safety and efficacy of a single subconjunctival injection of liposomal latanoprost was evaluated in six subjects with a diagnosis of either ocular hypertension (OHT) or primary open-angle glaucoma (POAG). Subconjunctival injection of liposomal latanoprost was well tolerated by all six subjects. From a baseline IOP of 27.55 ± 3.25 mmHg, the mean IOP decreased within 1 h to 14.52 ± 3.31 mmHg (range 10-18 mmHg). This represented a mean decrease of 13.03 ± 2.88 mmHg (range 9-17 mmHg), or 47.43 ± 10.05 % (range 37-63 %). A clinically and statistically significant IOP reduction (≥20 % IOP reduction, P = 0.001 to 0.049) was observed through 3 months after injection. The nanomedicine reported here is the first nanocarrier formulation that has an extended dura...Continue Reading

References

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Citations

Sep 11, 2014·Nanomedicine·Subbu Venkatraman, Tina Wong
Jul 12, 2016·Expert Opinion on Drug Metabolism & Toxicology·Alberto Aguayo BonniardCatherine M Birt
Feb 9, 2016·Expert Opinion on Emerging Drugs·Jed Asher Lusthaus, Ivan Goldberg
Sep 29, 2017·Drug Development and Industrial Pharmacy·Maryam KouchakLaleh Andishmand
Nov 28, 2017·Expert Opinion on Pharmacotherapy·Emily M SchehleinAlan L Robin
Dec 24, 2015·Asia-Pacific Journal of Ophthalmology·Sibel Cetinel, Carlo Montemagno
Dec 12, 2019·Advances in Therapy·Marcelo Luís OcchiuttoAnastasios G Konstas
Sep 9, 2017·International Ophthalmology Clinics·Michael M LinLouis R Pasquale
May 28, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gary D Novack, Melissa Barnett
Feb 12, 2017·Nanomedicine·Rini Rachel Joseph, Subbu S Venkatraman
Oct 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fidiniaina Rina JulianaMeihao Sun
Aug 22, 2020·International Journal of Nanomedicine·Song KwonJong Yeon Lee
Aug 26, 2014·Nanotechnology·Subbu Venkatraman
Dec 14, 2018·Pharmaceutical Research·Christopher M AdamsGanesh Prasanna
Oct 10, 2019·Expert Opinion on Therapeutic Patents·Claudiu T SupuranFabrizio Carta
Nov 10, 2020·Veterinary Ophthalmology·Paul E Miller, Joshua Seth Eaton
Dec 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Su Yin ChawSubbu Venkatraman
Dec 31, 2020·Pharmaceutics·Ognjenka RahićEdina Vranić
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Jan 21, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lixia LuoJustin Hanes
May 29, 2021·Journal of Glaucoma·Catherine Q ZhuManishi Desai

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