Nanomedicine to Deal With Cancer Cell Biology in Multi-Drug Resistance

Mini Reviews in Medicinal Chemistry
Pawan TekchandaniShivani Rai Paliwal

Abstract

Today Cancer still remains a major cause of mortality and death worldwide, in humans. Chemotherapy, a key treatment strategy in cancer, has significant hurdles such as the occurrence of chemoresistance in cancer, which is inherent unresponsiveness or acquired upon exposure to chemotherapeutics. The resistance of cancer cells to an antineoplastic agent accompanied to other chemotherapeutic drugs with different structures and mechanisms of action called multi-drug resistance (MDR) plays an important role in the failure of chemo- therapeutics. MDR is primarily based on the overexpression of drug efflux pumps in the cellular membrane, which belongs to the ATP-binding cassette (ABC) superfamily of proteins, are P-gp (P-glycoprotein) and multidrug resistance-associated protein (MRP). Over the years, various strategies have been evaluated to overcome MDR, based not only on the use of MDR modulators but also on the implementation an innovative approach and advanced nanosized drug delivery systems. Nanomedicine is an emerging tool of chemotherapy that focuses on alternative drug delivery for improvement of the treatment efficacy and reducing side effects to normal tissues. This review aims to focus on the details biology, reversal strat...Continue Reading

Citations

Jan 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·M R CarvalhoJ M Oliveira
Mar 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ruginn CatarataLei Zhai
Aug 28, 2020·International Journal of Biological Macromolecules·Balak Das KurmiShivani Rai Paliwal
Nov 18, 2020·Current Pharmaceutical Design·Shivani Rai PaliwalRishi Paliwal

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