Nanomedicines reveal how PBOV1 promotes hepatocellular carcinoma for effective gene therapy

Nature Communications
Yu GuoXintao Shuai

Abstract

There exists an urgent medical demand at present to develop therapeutic strategies which can improve the treatment outcome of hepatocellular carcinoma (HCC). Here, we explore the biological functions and clinical significance of PBOV1 in HCC in order to push forward the diagnosis and treatment of HCC. Using theranostical nanomedicines, PBOV1 is verified to be a key oncogene which greatly promotes HCC proliferation, epithelial-to-mesenchymal transition, and stemness by activating the Wnt/β-catenin signaling pathway. Therefore, single-chain antibody for epidermal growth factor receptor (scAb-EGFR)-targeted nanomedicine effectively silencing the PBOV1 gene exhibits potent anticancer effects. In vivo HCC-targeting siRNA delivery mediated by the theranostical nanomedicine remarkably inhibits the tumor growth and metastasis. In addition, the superparamagnetic iron oxide nanocrystals (SPION)-encapsulated nanomedicines possess high MRI detection sensitivity, which endows them with the potential for MRI diagnosis of HCC. This study shows that PBOV1 represents a prognostic biomarker and therapeutic target for HCC.

References

Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Sep 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Sep 21, 2010·Nature Cell Biology·Jolly MazumdarM Celeste Simon
Dec 29, 2010·Cell Research·Guobin He, Michael Karin
Apr 14, 2011·Expert Opinion on Therapeutic Targets·Hisayuki YaoTaira Maekawa
Jun 20, 2012·Nature Reviews. Gastroenterology & Hepatology·Avijit MajumdarLopa Mishra
Dec 10, 2013·Journal of Gastroenterology·Carmen Berasain, Matías A Avila
Sep 30, 2015·Nature·Andrea BertottiVictor E Velculescu
Dec 15, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Amy ZhouBenjamin Tan
Dec 19, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yu GuoXintao Shuai
Mar 5, 2016·OncoTargets and Therapy·Tiejun PanGuoqiu Shen
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery
Oct 22, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hsin-An ChenJen-Liang Su
Nov 1, 2016·Nature Nanotechnology·Laure Mercier de LépinayOlivier Arcizet
Dec 22, 2016·Nature Communications·Ines JericManuela Baccarini
Apr 12, 2017·Nature Reviews. Clinical Oncology·Tsukasa Shibue, Robert A Weinberg
Jun 10, 2017·Molecular Oncology·Meggy Suarez-CarmonaChristine Gilles
Aug 24, 2017·Pharmacology & Therapeutics·Mohini SinghSheila K Singh
Sep 16, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oriana Lo ReManlio Vinciguerra
Oct 7, 2017·Nature Medicine·Eduard Batlle, Hans Clevers

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Citations

Aug 18, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Yu-Shui MaDa Fu
Aug 9, 2020·Cancer Management and Research·Huining TianGuixia Wang
Jan 1, 2021·Frontiers in Oncology·Mariela Montaño-SamaniegoMiguel Ibáñez-Hernández
Jun 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xuexin LiZehuan Liao
May 29, 2019·Accounts of Chemical Research·Richard A ReviaMiqin Zhang

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Methods Mentioned

BETA
dynamic light scattering
electrophoresis
transmission electron microscopy
transfection
flow cytometry
fluorescence imaging
xenograft
affinity purification
PCR
FACS

Software Mentioned

Phoenix Flow
Carestream MI
FlowJo
SPSS

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