Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses

Particle and Fibre Toxicology
Isabella Radauer-PreimlAlbert Duschl

Abstract

Engineered nanomaterials (ENMs) interact with different biomolecules as soon as they are in contact, resulting in the formation of a biomolecule 'corona'. Hence, the 'corona' defines the biological identity of the ENMs and could affect the response of the immune system to ENM exposure. With up to 40 % of the world population suffering from type I allergy, a possible modulation of allergen effects by binding to ENMs is highly relevant with respect to work place and consumer safety. Therefore, the aim of this present study was to gain an insight into the interactions of gold nanoparticles with different seasonally and perennially occurring outdoor and indoor allergens. Gold nanoparticles (AuNPs) were conjugated with the major allergens of birch pollen (Bet v 1), timothy grass pollen (Phl p 5) and house dust mite (Der p 1). The AuNP-allergen conjugates were characterized by means of TEM negative staining, dynamic light scattering (DLS), z-potential measurements and hyperspectral imaging. Furthermore, 3D models were constructed, based on the characterization data, to visualize the interaction between the allergens and the AuNPs surface. Differences in the activation of human basophil cells derived from birch/grass pollen- and house...Continue Reading

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Citations

Jul 12, 2017·The Analyst·Debora BonvinMarijana Mionić Ebersold
Nov 22, 2017·Particle and Fibre Toxicology·Kirsty MeldrumMartin O Leonard
Feb 15, 2018·Current Environmental Health Reports·Mark D Ihrie, James C Bonner
Apr 25, 2019·Particle and Fibre Toxicology·Michael RiedikerFlemming Cassee
Apr 13, 2019·International Journal of Molecular Sciences·Marina P SutunkovaBoris A Katsnelson
May 11, 2017·Frontiers in Immunology·Martin HimlyAlbert Duschl
Sep 27, 2019·Current Pharmaceutical Design·Romina MitarotondaMauricio C De Marzi
Mar 19, 2021·Advanced Healthcare Materials·Daniil A VishnevskiyVictor A Naumenko

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Methods Mentioned

BETA
lavages
NMR
flow cytometry
FCS
infrared
X-ray

Software Mentioned

GraphPad Prism
UCSF Chimera package
APBS
PARSE
FACSDiva
Excel
PDB2PQR

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