Nanoparticle approaches to combating drug resistance

Future Medicinal Chemistry
Jae Hyon MoonHonggang Cui

Abstract

Multidrug resistance (MDR) among cancer cells is a serious impediment to the success of conventional chemotherapy. The emergence of nanomedicine demonstrates great promise in overcoming MDR through multiple mechanisms. Nanoparticles have been shown to overcome the MDR at the tissue level through increased intratumoral accumulation resulting from enhanced permeation and retention, neovascular cell targeting, and externally triggered local drug release. Nanoparticles have also demonstrated the ability to overcome the MDR at the cellular/subcellular level by enhancing intracellular drug accumulation, improving drug-target accessibility, or even interfering with existing MDR mechanisms.

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Citations

Jun 24, 2018·Journal of Biomaterials Applications·Marzieh KeshavarzAli Shakeri-Zadeh
Mar 27, 2019·Nanomaterials·Laura Bayón-CorderoLide Arana
Nov 23, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qida HuTingbo Liang
May 24, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sabina Quader, Kazunori Kataoka

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Methods Mentioned

BETA
surgical resection

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