Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality.

Scientific Reports
Lauren E WoodardRobert Ivkov

Abstract

Magnetic iron oxide nanoparticles (MIONs) have established a niche as a nanomedicine platform for diagnosis and therapy, but they present a challenging surface for ligand functionalization which limits their applications. On the other hand, coating MIONs with another material such as gold to enhance these attachments introduces other complications. Incomplete coating may expose portions of the iron oxide core, or the coating process may alter their magnetic properties. We describe synthesis and characterization of iron oxide/silica/gold core-shell nanoparticles to elucidate the effects of a silica-gold coating process and its impact on the resulting performance. In particular, small angle neutron scattering reveals silica intercalates between iron oxide crystallites that form the dense core, likely preserving the magnetic properties while enabling formation of a continuous gold shell. The synthesized silica-gold-coated MIONs demonstrate magnetic heating properties consistent with the original iron oxide core, with added x-ray contrast for imaging and laser heating.

References

Nov 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M MitsumoriM Abe
Mar 26, 2002·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S K JonesB N Gray
May 26, 2004·Cancer Letters·D Patrick O'NealJennifer L West
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sally J DeNardoRobert Ivkov
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert IvkovGerald L DeNardo
Oct 28, 2006·Annual Review of Physical Chemistry·Katherine A Willets, Richard P Van Duyne
Apr 14, 2007·Analytical Chemistry·Shalini GuptaOrlin D Velev
May 25, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M JohannsenS A Loening
Jul 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gerald L DeNardoRodney L Balhorn
Aug 4, 2007·Lasers in Medical Science·Xiaohua HuangMostafa A El-Sayed
May 30, 2008·Advanced Drug Delivery Reviews·Jason R McCarthy, Ralph Weissleder
Jul 22, 2008·International Journal of Radiation Oncology, Biology, Physics·John WongTheodore L DeWeese
Apr 6, 2007·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Xiaojun JiChun Li
Apr 21, 2010·Annals of Surgical Oncology·Eleni Liapi, Jean-Francois H Geschwind
Aug 17, 2010·Advanced Drug Delivery Reviews·Siti M JanibJ Andrew MacKay
Nov 19, 2010·Radiology·Stephen B Solomon, Stuart G Silverman
Oct 7, 2011·Molecular Pharmaceutics·Ruth Duncan, Rogerio Gaspar
Nov 1, 2011·Chemical Society Reviews·Ken Cham-Fai LeungBerton C-T Chung
Feb 14, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ananda KumarRobert Ivkov
Apr 30, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Z KarimiH Shokrollahi
Sep 21, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Tiago R OliveiraMark W Dewhirst
Oct 18, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Cindi L Dennis, Robert Ivkov
Apr 30, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Michele WablerDmitri Artemov
Mar 27, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Anilchandra AttaluriRobert Ivkov
May 7, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Anilchandra AttaluriEleni Liapi
Aug 2, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mohammad HedayatiRobert Ivkov

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Citations

Feb 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana-Maria PutzCristina Dehelean
Jan 12, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Anilchandra AttaluriRobert Ivkov
Apr 16, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sri Kamal KandalaAnilchandra Attaluri
Jun 3, 2021·Nanomaterials·Mariam Abdulaziz M TarkistaniVeysel Kayser
Nov 23, 2021·Chemical Communications : Chem Comm·Milad MehdipourJ Justin Gooding

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Methods Mentioned

BETA
surface plasmon resonance
small angle neutron scattering
xenograft
dynamic
transmission electron microscopy
Dynamic light scattering
angle
SANS
x-ray CT
xenografts

Software Mentioned

SasView
ImageJ
Igor Pro

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