Nanoparticle-Assisted Combinatorial Therapy for Effective Treatment of Endometriosis

Journal of Biomedical Nanotechnology
Abhay Kumar SinghKoel Chaudhury

Abstract

Endometriosis is characterized by the presence of endometrial glands and stroma outside the uterine cavity. Conventional treatment modalities for endometriosis are unsatisfactory; therefore, there is a need to treat the underlying causes and mechanism. Oxidative stress, extracellular matrix degradation, and angiogenesis are associated with the pathogenesis of endometriosis. The anti-angiogenic and antioxidant properties of epigallocatechin gallate and the matrix metalloproteinase inhibitory activity of the antibiotic doxycycline are well established. However, epigallocatechin gallate and doxycycline have several limitations when used in their native forms. This motivated us to synthesize dual drug-loaded (epigallocatechin gallate and doxycycline) nanoparticles and check their therapeutic efficacy in mice with induced endometriosis. The synthesized nanoparticles displayed features of a promising drug-delivery system, such as small size, high encapsulation efficiency, controlled drug release, and low toxicity. The serum of endometriosis-induced mice and controls was assessed for various oxidative stress markers, matrix-degrading enzymes, and angiogenic markers before and after nanoparticle administration. Endometrial glands, stro...Continue Reading

Citations

Aug 23, 2017·Drug Delivery and Translational Research·David R Friend
Jan 30, 2018·Frontiers in Pharmacology·Mariana H RemiãoTiago Collares
Nov 7, 2017·Journal of Basic Microbiology·Alireza JafariAli Majidpour
Sep 29, 2020·Expert Opinion on Drug Delivery·Simone GarzonSimone Ferrero
Nov 24, 2020·Clinical and Experimental Reproductive Medicine·Ruchita ShandilyaPradyumna Kumar Mishra
Jan 26, 2021·Small·Abraham S MosesOleh Taratula
Oct 31, 2020·Human Reproduction Update·Gabriela F MeresmanMatthias W Laschke
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Nesrein M Hashem, Antonio Gonzalez-Bulnes
Aug 28, 2021·Nutrients·Ludovica BartiromoMassimo Candiani

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