Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology

Dose-response : a Publication of International Hormesis Society
Lina YanSaijun Lu

Abstract

Chemotherapy is widely used to treat cancer. The toxic effect of conventional chemotherapeutic drugs on healthy cells leads to serious toxic and side effects of conventional chemotherapy. The application of nanotechnology in tumor chemotherapy can increase the specificity of anticancer agents, increase the killing effect of tumors, and reduce toxic and side effects. Currently, a variety of formulations based on nanoparticles (NPs) for delivering chemotherapeutic drugs have been put into clinical use, and several others are in the stage of development or clinical trials. In this review, after briefly introducing current cancer chemotherapeutic methods and their limitations, we describe the clinical applications and advantages and disadvantages of several different types of NPs-based chemotherapeutic agents. We have summarized a lot of information in tables and figures related to the delivery of chemotherapeutic drugs based on NPs and the design of NPs with active targeting capabilities.

References

Jul 16, 1992·Nature·X M He, D C Carter
Nov 1, 1973·FEBS Letters·G Gregoriadis
Dec 4, 1993·Lancet·J LiebmannJ B Mitchell
Jan 1, 1994·Advances in Protein Chemistry·D C Carter, J X Ho
Mar 7, 2002·International Journal of Pharmaceutics·Anil K SinglaDeepika Aggarwal
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Hisae IinumaYutaka Yonemura
May 13, 2003·Clinical Pharmacokinetics·Alberto GabizonYechezkel Barenholz
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian F TannockFrits S Van Dam
Jul 17, 2004·Neoplasia : an International Journal for Oncology Research·Dan Peer, Rimona Margalit
Aug 24, 2004·Cancer Chemotherapy and Pharmacology·Klaus MrossChristine E Swenson
Jan 5, 2005·Nature Reviews. Cancer·Bruce A Chabner, Thomas G Roberts
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Igor V ZhigaltsevPieter R Cullis
Sep 2, 2005·Journal of Pharmaceutical Sciences·Andrew R Hilgenbrink, Philip S Low
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William J GradisharJoyce O'Shaughnessy
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David W NymanDaniel D Von Hoff
Aug 22, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tracy R DanielsManuel L Penichet
Sep 26, 2006·International Journal of Pharmaceutics·Tomotaka KobayashiHiroshi Kiwada
Mar 22, 2007·JAMA : the Journal of the American Medical Association·Nobuko HijiyaChing-Hon Pui
May 15, 2007·Acta Oncologica·Marianne BrydøyTrine Bjøro
Sep 20, 2007·Expert Opinion on Drug Safety·Neena I MarupudiHenry Brem
Apr 2, 2008·The Oncologist·William C Zamboni
Dec 17, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H MaedaJ Daruwalla
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tamer A ElBayoumi, Vladimir P Torchilin
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hilary ShmeedaAlberto Gabizon
May 8, 2009·Current Opinion in Chemical Biology·Philip Stewart Low, Sumith Anurasiri Kularatne
May 12, 2009·International Journal of Pharmaceutics·XueMing LiQiNeng Ping
Jul 17, 2009·Expert Opinion on Investigational Drugs·Teni Boulikas
Aug 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Daryl C DrummondDmitri B Kirpotin
May 5, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G P StathopoulosG Tsoukalas
Aug 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
Sep 3, 2010·Investigational New Drugs·Shih-Hung YangRuey-Long Hong
Sep 28, 2010·Advanced Drug Delivery Reviews·Kazuo Maruyama
Dec 28, 2010·International Journal of Pharmaceutics·Karsten UlbrichJörg Kreuter
Feb 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J FeldmanArthur C Louie
Jun 23, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U FasolK Mross
Mar 3, 2012·Current Heart Failure Reports·Amir Y Shaikh, Jeffrey A Shih
Apr 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yechezkel Barenholz
Aug 21, 2012·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Gulbeyaz CanAdnan Aydiner
Aug 28, 2012·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nitzan Gonen, Yehuda G Assaraf
Sep 4, 2012·Cancer Chemotherapy and Pharmacology·Jeffrey R InfanteHoward A Burris
Jan 8, 2013·Expert Opinion on Drug Delivery·Jonathan P May, Shyh-Dar Li
Jun 14, 2013·BioMed Research International·Hui XieDanqiu Zhou

❮ Previous
Next ❯

Citations

Mar 5, 2021·International Journal of Nanomedicine·Ruixin JiaYe Bi
Apr 20, 2021·Expert Opinion on Investigational Drugs·Jessica Gartrell, Carlos Rodriguez-Galindo
Jun 3, 2021·Cancers·Esra Küpeli AkkolRaffaele Capasso

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
xenografts

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Pharmaceutical Biotechnology
Eduardo HerrerosRicardo Fernández-Ramires
Journal of Drug Targeting
Suphiya Parveen, Sanjeeb K Sahoo
Materials Science & Engineering. C, Materials for Biological Applications
Sepideh Zununi VahedSimin Sharifi
© 2021 Meta ULC. All rights reserved