Nanoparticle-Based Estrogen Delivery to Spinal Cord Injury Site Reduces Local Parenchymal Destruction and Improves Functional Recovery.

Journal of Neurotrauma
April CoxNaren L Banik

Abstract

Spinal cord injury (SCI) patients sustain significant functional impairments; this is causally related to restricted neuronal regeneration after injury. The ensuing reactive gliosis, inflammatory cascade, and glial scar formation impede axonal regrowth. Although systemic anti-inflammatory agents (steroids) have been previously administered to counteract this, no current therapeutic is approved for post-injury neuronal regeneration, in part because of related side effects. Likewise, therapeutic systemic estrogen levels exhibit neuroprotective properties, but dose-dependent side effects are prohibitive. The current study thus uses low-dose estrogen delivery to the spinal cord injury (SCI) site using an agarose gel patch embedded with estrogen-loaded nanoparticles. Compared to controls, spinal cords from rodents treated with nanoparticle site-directed estrogen demonstrated significantly decreased post-injury lesion size, reactive gliosis, and glial scar formation. However, axonal regeneration, vascular endothelial growth factor production, and glial-cell-derived neurotrophic factor levels were increased with estrogen administration. Concomitantly improved locomotor and bladder functional recovery were observed with estrogen admini...Continue Reading

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Citations

Jan 27, 2021·Neurochemistry International·Hun-Jin JeongSo-Jung Gwak
Feb 19, 2021·Metabolic Brain Disease·Vandana ZamanNarendra L Banik

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
Protein Assay
transgenic

Software Mentioned

DigiGait
GraphPad
ImageJ
Prism
StatView

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