Nanoparticle-Based Manipulation of Antigen-Presenting Cells for Cancer Immunotherapy

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Ronnie H FangLiangfang Zhang

Abstract

Immunotherapeutic approaches for treating cancer overall have been receiving a considerable amount of interest due to the recent approval of several clinical formulations. Among the different modalities, anticancer vaccination acts by training the body to endogenously generate a response against tumor cells. However, despite the large amount of work that has gone into the development of such vaccines, the near absence of clinically approved formulations highlights the many challenges facing those working in the field. The generation of potent endogenous anticancer responses poses unique challenges due to the similarity between cancer cells and normal, healthy cells. As researchers continue to tackle the limited efficacy of vaccine formulations, fresh and novel approaches are being sought after to address many of the underlying problems. Here the application of nanoparticle technology towards the development of anticancer vaccines is discussed. Specifically, there is a focus on the benefits of using such strategies to manipulate antigen presenting cells (APCs), which are essential to the vaccination process, and how nanoparticle-based platforms can be rationally engineered to elicit appropriate downstream immune responses.

References

Jul 1, 1991·Clinical and Experimental Immunology·S K Law
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H C HooverM G Hanna
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eri KanaokaKoichiro Hirano
Oct 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina FonsecaRogério Gaspar
Jan 16, 2003·Immunology Letters·Shizuo Akira, Hiroaki Hemmi
Apr 3, 2003·Immunological Reviews·Leonard J Appleman, Vassiliki A Boussiotis
Jan 7, 2004·Nature Reviews. Cancer·Glenn Dranoff
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tae-You KimYung-Jue Bang
Sep 2, 2004·Nature Medicine·Steven A RosenbergNicholas P Restifo
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Lizzia RaffaghelloVito Pistoia
Apr 5, 2005·Molecular Pharmaceutics·Zhengrong CuiLeaf Huang
Jun 7, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Young Jik KwonJean M J Fréchet
Feb 21, 2006·Nature·J Magarian Blander, Ruslan Medzhitov
Mar 15, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sai T ReddyMelody A Swartz
May 30, 2006·Advances in Immunology·Charles G DrakeDrew M Pardoll
Jun 3, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R GreenM J Hawkins
Jul 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J SmallRobert M Hershberg
Aug 29, 2006·Drug Discovery Today·Arun K IyerHiroshi Maeda
Sep 19, 2006·Advanced Drug Delivery Reviews·Z Tabi, S Man
Oct 25, 2006·Molecular Membrane Biology·Dileep P VangasseriLeaf Huang
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomofumi UtoMasanori Baba
Mar 28, 2007·Immunology·Ryungsa KimKazuaki Tanabe
Apr 26, 2007·Journal of Immunotherapy·Praveen ElamanchiliJohn Samuel
May 4, 2007·The Journal of Clinical Investigation·Jeremy B Swann, Mark J Smyth
Jun 6, 2007·The Journal of Clinical Investigation·Carl H June
Aug 29, 2007·Cancer Immunology, Immunotherapy : CII·Weihsu ChenLeaf Huang
Sep 18, 2007·Nature Biotechnology·Sai T ReddyJeffrey A Hubbell
Dec 11, 2007·Biochemical and Biophysical Research Communications·Tomoaki YoshikawaShinsaku Nakagawa
Jan 18, 2008·European Journal of Immunology·Kuo-Ching ShengGeoffrey A Pietersz
Feb 26, 2008·Bulletin of the World Health Organization·F E AndreH J Schmitt

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Citations

May 6, 2016·Annual Review of Chemical and Biomolecular Engineering·Ronnie H Fang, Liangfang Zhang
Dec 8, 2016·Macromolecular Bioscience·Samagya BanskotaAshutosh Chilkoti
Jul 30, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Flavia FontanaHélder A Santos
May 18, 2016·Experimental Biology and Medicine·Sourabh Shukla, Nicole F Steinmetz
Jun 27, 2017·Nature Nanotechnology·Yuanzeng MinAndrew Z Wang
Mar 28, 2018·Advanced Materials·Ronnie H FangLiangfang Zhang
Jan 23, 2019·Advanced Healthcare Materials·Eun Sook LeeJae Hyung Park
Jun 18, 2019·Advanced Materials·Jiarong ZhouLiangfang Zhang
Jul 3, 2019·Current Pharmaceutical Design·Adrian Rodríguez-CarlosBruno Rivas-Santiago
Apr 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro Baeza
Mar 16, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Hui QiuAndrew Z Wang
Mar 4, 2020·Acta Pharmacologica Sinica·Fan YangZhi-Yong Qian
Nov 16, 2019·Advanced Biosystems·Ashley V KrollLiangfang Zhang
Jan 21, 2020·Archives of Pharmacal Research·Md AsadujjamanJun-Pil Jee
Aug 3, 2019·European Journal of Medicinal Chemistry·Lucia BiasuttoMario Zoratti
Jan 18, 2021·Cancer Treatment and Research Communications·Ajinkya Madhukar ThanekarAravind Kumar Rengan
Dec 9, 2020·Advanced Materials·Mengyu ChangJun Lin
Feb 16, 2021·Advanced Healthcare Materials·Faisal RazaQiu Mingfeng
Dec 7, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Ignacio Morales-OruePedro C Lara
May 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yao JiangLiangfang Zhang
Mar 16, 2017·Biomaterials·Ronnie H FangLiangfang Zhang
Aug 7, 2017·Trends in Cancer·Shiladitya Sengupta
Aug 24, 2020·Biotechnology Progress·Pourya NasirmoghadasMohammad Amin Jadidi Kouhbanani
Nov 15, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Dan WuShuqi Wang
Jun 24, 2021·Biomaterials Science·Hajra ZafarQi Shen
Jul 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Binbin DingJun Lin
Aug 7, 2021·Molecular Aspects of Medicine·Jiarong ZhouLiangfang Zhang
Aug 8, 2021·Cells·Grant R Campbell, Stephen A Spector
Aug 10, 2021·ACS Applied Bio Materials·Maya HolayLiangfang Zhang
Mar 14, 2018·Molecular Pharmaceutics·Brian T LukLiangfang Zhang

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