Nanoparticle cytotoxicity depends on intracellular solubility: comparison of stabilized copper metal and degradable copper oxide nanoparticles

Toxicology Letters
Andreas M StuderWendelin J Stark

Abstract

Metal nanoparticles have distinctly different chemical and physical properties than currently investigated oxides. Since pure metallic nanoparticles are igniting at air, carbon stabilized copper nanoparticles were used as representative material for this class. Using copper as a representative example, we compare the cytotoxicity of copper metal nanoparticles stabilized by a carbon layer to copper oxide nanoparticles using two different cell lines. Keeping the copper exposure dose constant, the two forms of copper showed a distinctly different response. Whilst copper oxide had already been reported to be highly cytotoxic, carbon-coated copper nanoparticles were much less cytotoxic and more tolerated. Measuring the two material's intra- and extracellular solubility in model buffers explained this difference on the basis of altered copper release when supplying copper metal or the corresponding oxide particles to the cells. Control experiments using pure carbon nanoparticles were used to exclude significant surface effects. Reference experiments with ionic copper solutions confirmed a similar response of cultures if exposed to copper oxide nanoparticles or ionic copper. These observations are in line with a Trojan horse-type mech...Continue Reading

Citations

Aug 24, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Paweł SzymańskiElżbieta Mikiciuk-Olasik
Jul 9, 2013·Nanoscale Research Letters·Mona ConnollyJosé M Navas
Jun 1, 2011·Analytical and Bioanalytical Chemistry·Silvia DiabatéCarsten Weiss
Jan 14, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wan-Seob ChoKen Donaldson
Jul 27, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rasmus FoldbjergChristiane Beer
Mar 20, 2013·BioMed Research International·Rossella BengalliMaurizio Gualtieri
Mar 27, 2012·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Anne HahnStephan Barcikowski
Feb 10, 2016·Colloids and Surfaces. B, Biointerfaces·Jonas HedbergInger Odnevall Wallinder
Jul 16, 2014·International Journal of Molecular Sciences·Larisa I PrivalovaSvetlana V Kostykova
Jan 22, 2015·International Journal of Molecular Sciences·Humberto Palza
Nov 26, 2014·International Journal of Molecular Sciences·Larisa I PrivalovaSvetlana V Beljayeva
Mar 6, 2015·International Journal of Molecular Sciences·Natalia Mroczek-SosnowskaAndré Chwalibog
Apr 22, 2015·Journal of Microbiological Methods·Mark SibagJinwoo Cho
Mar 29, 2014·Journal of Food and Drug Analysis·Peter P FuHongtao Yu
Nov 13, 2012·Toxicology and Applied Pharmacology·Morag PrachLorna Proudfoot
Jul 17, 2015·Environmental Toxicology and Chemistry·Michael J MashockKrassimira R Hristova
Feb 27, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Masanori HashimotoSatoshi Imazato
Nov 22, 2011·Toxicology Letters·Christiane BeerHerman Autrup
Oct 22, 2011·Journal of Hazardous Materials·Jian ZhaoBaoshan Xing
Mar 9, 2011·Environmental Toxicology·Masanori HorieHitoshi Iwahashi
Apr 10, 2016·Water Research·Martin TroesterThilo Hofmann
May 1, 2015·Particle and Fibre Toxicology·Wells UtembeMary Gulumian
Oct 26, 2013·Particle and Fibre Toxicology·Wan-Seob ChoKen Donaldson
Dec 26, 2013·BioMed Research International·Lotfi Barhoumi, David Dewez
May 28, 2015·Journal of Applied Toxicology : JAT·Saura C SahuXiugong Gao
Mar 11, 2015·Journal of Applied Toxicology : JAT·Anna MurphyGordon Chambers
Jun 2, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ylva RodheLennart Möller

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