Nanoparticle Deposition in Rhythmically Moving Acinar Models with Interalveolar Septal Apertures

Nanomaterials
Jinxiang Xi, Mohamed Talaat

Abstract

Pulmonary delivery of nanomedicines has been extensively studied in recent years because of their enhanced biocompatibility, sustained-release properties, and surface modification capability. The lung as a target also offers many advantages over other routers, such as large surface area, noninvasive, quick therapeutic onset, and avoiding first-pass metabolism. However, nanoparticles smaller than 0.26 µm typically escape phagocytosis and remain in the alveoli for a long time, leading to particle accumulation and invoking tissue responses. It is imperative to understand the behavior and fates of inhaled nanoparticles in the alveoli to reliably assess therapeutic outcomes of nanomedicines or health risk of environmental toxins. The objective of this study is to numerically investigate nanoparticle deposition in a duct-alveolar model with varying sizes of inter-alveolar septal apertures (pores). A discrete phase Lagrangian model was implemented to track nanoparticle trajectories under the influence of rhythmic wall expansion and contraction. Both temporal and spatial dosimetry in the alveoli were computed. Wall motions are essential for nanoparticles to penetrate the acinar region and deposit in the alveoli. The level of aerosol ir...Continue Reading

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Citations

Dec 15, 2019·Animals : an Open Access Journal From MDPI·Jinxiang XiRichard Corley
Oct 4, 2020·Respiratory Physiology & Neurobiology·Jinxiang XiHiroko Kitaoka
Aug 28, 2021·Environmental Science and Pollution Research International·Kuan-Jen BaiHsiao-Chi Chuang

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