Nanoparticle formation by using shellac and chitosan for a protein delivery system

Pharmaceutical Development and Technology
Pakorn KraisitManee Luangtana-anan

Abstract

The potential of using two natural polymers (chitosan and shellac) for the formation of nanoparticles by the process of ionic cross-linking to encapsulate bovine serum albumin, a model protein was investigated. Depending on the concentrations of chitosan, shellac and bovine serum albumin, three physical states - nanoparticle, aggregation, and solution could be observed as a result of the electrostatic force. The formation of nanoparticles was due to the balance between the repulsion force and attractive force while the imbalance between both forces resulted in the formation of aggregation and solution. The Fourier transform infrared spectroscopy and differential scanning calorimetry were applied to prove the nanoparticle formation. The particle size was characterized by the light scattering technique and was found in the range between 100 and 300 nm. The morphology of the particles, detected by transmission electron microscopy was spherical shape. The result showed that the zeta potential of the nanoparticles possessed positive charges. The concentrations of chitosan, shellac and bovine serum albumin had an influence on the physicochemical properties of the nanoparticles such as the particle size, the zeta potential, the encaps...Continue Reading

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Citations

Jun 2, 2016·Critical Reviews in Biotechnology·Farnaz AssaAydin Berenjian
Apr 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pakorn Kraisit, Narong Sarisuta

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