Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

Oncotarget
Chao-Chih WuChih-Long Chang

Abstract

Hyperthermic intraperitoneal chemotherapy is effective in treating various intra-abdominal malignancies. However, this therapeutic modality can only be performed during surgical operations and cannot be used repeatedly. We propose repeatedly noninvasive hyperthermia mediated by pegylated silica-core gold nanoshells (pSGNs) in vivo with external near-infrared (NIR) laser irradiation. This study demonstrated that repeated photothermal treatment can effectively eliminate intraperitoneal tumors in mouse ovarian cancer models without damage of normal tissues. By conjugating pSGNs with anti-human CD47 monoclonal antibody, a significant photoablative effect can be achieved using lower amount of pSGNs and shorter NIR laser irradiation. Conjugated pSGNs specifically targeted and bound to cancer cells inside the peritoneal cavity. Our results indicate the possibility of a noninvasive method of repeated hyperthermia and photoablative therapies using nanoparticles. This has substantial clinical potential in treating ovarian and other intraperitoneal cancers.

References

Apr 3, 2001·Nature Biotechnology·R Weissleder
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Jan 31, 2004·Technology in Cancer Research & Treatment·Christopher LooRebekah Drezek
Feb 12, 2004·Cancer Research·Partha Pratim Manna, William A Frazier
May 26, 2004·Cancer Letters·D Patrick O'NealJennifer L West
Apr 14, 2005·Nano Letters·Christopher LooRebekah Drezek
May 13, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P A VaseyUNKNOWN ESMO Guidelines Task Force
Aug 29, 2007·International Journal of Nanomedicine·Amanda R LoweryJennifer L West
Dec 7, 2007·Disease Markers·Donna Badgwell, Robert C Bast
May 23, 2009·Nature Reviews. Cancer·Robert C BastGordon B Mills
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Keith Syson ChanIrving L Weissman
Mar 11, 2010·Breast Cancer Research and Treatment·Laura B CarpinRebekah A Drezek
Nov 11, 2010·Future Oncology·Ze LuJessie L-S Au
Nov 27, 2010·Journal of Neuro-oncology·Emily S DayJennifer L West
Dec 24, 2010·Cancer Research·Mark P ChaoRavindra Majeti
Feb 15, 2012·Journal of Experimental & Clinical Cancer Research : CR·Ayako KimTakayuki Enomoto
Apr 17, 2012·Therapeutic Delivery·Dev Kumar ChatterjeeSunil Krishnan
Sep 11, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eiji KobayashiTakayuki Enomoto
Oct 31, 2012·Cancer Research·Chih-Long ChangChien-Fu Hung
Jul 9, 2013·Journal of Biomedical Optics·Ammar AbdoMesut Sahin
Oct 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Li TangJianjun Cheng

❮ Previous
Next ❯

Methods Mentioned

BETA
surface plasmon resonance
flow cytometry
xenograft

Software Mentioned

ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved