Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy

Biomaterials
Ivan S AlferievMichael Chorny

Abstract

Nanomedicine-based strategies have the potential to improve therapeutic performance of a wide range of anticancer agents. However, the successful implementation of nanoparticulate delivery systems requires the development of adequately sized nanocarriers delivering their therapeutic cargo to the target in a protected, pharmacologically active form. The present studies focused on a novel nanocarrier-based formulation strategy for SN-38, a topoisomerase I inhibitor with proven anticancer potential, whose clinical application is compromised by toxicity, poor stability and incompatibility with conventional delivery vehicles. SN-38 encapsulated in biodegradable sub-100 nm sized nanoparticles (NP) in the form of its rapidly activatable prodrug derivative with tocopherol succinate potently inhibited the growth of neuroblastoma cells in a dose- and exposure time-dependent manner, exhibiting a delayed response pattern distinct from that of free SN-38. In a xenograft model of neuroblastoma, prodrug-loaded NP caused rapid regression of established large tumors, significantly delayed tumor regrowth after treatment cessation and markedly extended animal survival. The NP formulation strategy enabled by a reversible chemical modification of t...Continue Reading

References

Dec 18, 2001·The Oncologist·L BomgaarsS M Blaney
Mar 21, 2002·Histopathology·D C Brown, K C Gatter
Oct 22, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael ChornyGershon Golomb
Apr 4, 2003·Journal of the American College of Nutrition·Kedar N PrasadWilliam C Cole
Oct 27, 2004·Journal of Nanoscience and Nanotechnology·Rainer H Müller, Cornelia M Keck
Jan 20, 2006·Pharmaceutical Research·Panayiotis P ConstantinidesStanley S Davis
Sep 23, 2006·Nature Reviews. Cancer·Yves Pommier
Mar 18, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nir DebottonSimon Benita
Mar 29, 2008·Bioconjugate Chemistry·Hong ZhaoIvan D Horak
May 6, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·May P XiongM Laird Forrest
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Nov 28, 2008·Molecular Pharmaceutics·Peisheng XuYoon Yeo
Dec 17, 2008·Molecular Nutrition & Food Research·Yan ZhaoKun Wu
Apr 7, 2009·Nano Letters·Steven D PerraultWarren C W Chan
Jul 1, 2009·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Fatemeh AtyabiRassoul Dinarvand
Jan 30, 2010·Molecular Pharmaceutics·Vincent J Venditto, Eric E Simanek
May 7, 2010·Current Pharmaceutical Design·J M Férriz, J Vinsová
Aug 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fabio PastorinoMirco Ponzoni
Nov 26, 2010·Molecular BioSystems·Jonathan GunnMiqin Zhang
Sep 29, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Twan LammersGert Storm
Apr 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yechezkel Barenholz
Apr 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexander T Florence
Apr 13, 2012·Molecular Pharmaceutics·Yunqi ZhaoM Laird Forrest
Jun 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qihang SunYouqing Shen
Jul 10, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Rachael M CristScott E McNeil
Dec 18, 2012·Nano Today·Joseph W Nichols, You Han Bae
Jan 22, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Heidi M Kieler-FergusonFrancis C Szoka
Feb 7, 2013·International Journal of Pharmaceutics·Tobias MillerAchim Goepferich
Aug 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vaskor BalaClive A Prestidge
Dec 19, 2013·Chemical Communications : Chem Comm·Daniel HofmannVolker Mailänder
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jillian E TengoodMichael Chorny
Mar 19, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nicolas DuhemVéronique Préat
Feb 3, 2016·Drug Metabolism and Pharmacokinetics·Chalirmporn AtasilpChonlaphat Sukasem

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Citations

Dec 26, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Richard F AdamoMichael Chorny
Jan 13, 2017·Molecular Pharmaceutics·Danielle IrbyFeng Li
Jan 13, 2019·The Journal of Pharmacology and Experimental Therapeutics·Carlos Rodríguez-NogalesMaría J Blanco-Prieto
Apr 25, 2020·Anti-cancer Agents in Medicinal Chemistry·Joseph MazarTamarah J Westmoreland
Mar 9, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ferro NguyenGarrett M Brodeur
Dec 24, 2019·International Journal of Biological Macromolecules·Chandrasekaran MurugesanMuralitharan Gangatharan
Sep 9, 2019·ACS Biomaterials Science & Engineering·Vedagopuram Sreekanth, Avinash Bajaj

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