Nanoparticle-Mediated Drug Delivery for Treatment of Ischemic Heart Disease

Frontiers in Bioengineering and Biotechnology
Chengming FanWuqiang Zhu

Abstract

The regenerative capacity of an adult cardiac tissue is insufficient to repair the massive loss of heart tissue, particularly cardiomyocytes (CMs), following ischemia or other catastrophic myocardial injuries. The delivery methods of therapeutics agents, such as small molecules, growth factors, exosomes, cells, and engineered tissues have significantly advanced in medical science. Furthermore, with the controlled release characteristics, nanoparticle (NP) systems carrying drugs are promising in enhancing the cardioprotective potential of drugs in patients with cardiac ischemic events. NPs can provide sustained exposure precisely to the infarcted heart via direct intramyocardial injection or intravenous injection with active targets. In this review, we present the recent advances and challenges of different types of NPs loaded with agents for the repair of myocardial infarcted heart tissue.

References

Sep 21, 2002·Lancet·Eriko Tateishi-YuyamaUNKNOWN Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators
Oct 23, 2004·Science·K S NovoselovA A Firsov
Aug 23, 2005·Chemical Communications : Chem Comm·Meredith T MorganMark W Grinstaff
Jul 21, 2006·Nature·Sasha StankovichRodney S Ruoff
Jan 9, 2007·Cardiovascular Research·Jianli NiuPappachan E Kolattukudy
Mar 3, 2007·Nature Materials·A K Geim, K S Novoselov
Sep 3, 2008·Chemical Society Reviews·Ralph A SperlingWolfgang J Parak
Dec 18, 2008·Handbook of Experimental Pharmacology·Lincoln R PotterDeborah M Dickey
Jan 22, 2010·Circulation·Donald M Lloyd-JonesUNKNOWN American Heart Association Strategic Planning Task Force and Statistics Committee
Jan 1, 2008·Nano Research·Xiaoming SunHongjie Dai
Jan 29, 2011·Nanoscale·Liangzhu FengZhuang Liu
Feb 15, 2011·Journal of Molecular and Cellular Cardiology·Sachiko KankiRichard T Lee
Apr 6, 2011·The Journal of Pharmacology and Experimental Therapeutics·Jianli NiuPappachan E Kolattukudy
Oct 15, 2011·Nanoscale Research Letters·Wuxu ZhangYingge Zhang
Jul 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leonie E PaulisGustav J Strijkers
Sep 6, 2012·Therapeutic Delivery·Ryan M PearsonSeungpyo Hong
Oct 6, 2012·Advanced Drug Delivery Reviews·Theresa M Allen, Pieter R Cullis
Mar 16, 2013·Advanced Materials·Dimitrios BitounisKostas Kostarelos
May 15, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ming-Yao ChangPatrick C H Hsieh
Aug 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Ebabe ElleJ M Rouanet
Jul 22, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Baljeet SinghGoutam Rath
Jan 7, 2016·Annual Review of Food Science and Technology·Kang Pan, Qixin Zhong
Feb 2, 2016·International Journal of Pharmaceutics·Muhammad Imran SajidAbdelhamid Elaissari
Feb 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Justina Roxana VirlanMaria Greabu
Apr 24, 2016·Biomaterials·Mónica P A FerreiraHélder A Santos
Apr 28, 2016·Chemical Society Reviews·Di Sheng LeeDavid Tai Leong

❮ Previous
Next ❯

Citations

Mar 26, 2021·Cancer Immunology, Immunotherapy : CII·Kyp L OxleyGail A Bishop
Apr 4, 2021·Pharmaceutics·Rajasekharreddy PalaSurya M Nauli
Jun 26, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Nour K YounisAli H Eid

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass
antisense oligonucleotide
biosensing
transfection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Cardiology
S GudbjarnasonR J Bing
Cardiologia : bollettino della Società italiana di cardiologia
S GudbjarnasonR J Bing
Current Opinion in Pharmacology
Kai C Wollert
Cardiologia : bollettino della Società italiana di cardiologia
P AnversaP Li
© 2021 Meta ULC. All rights reserved