Nanoparticle-mediated photothermal effect enables a new method for quantitative biochemical analysis using a thermometer

Nanoscale
Guanglei FuXiuJun Li

Abstract

A new biomolecular quantitation method, nanoparticle-mediated photothermal bioassay, using a common thermometer as the signal reader was developed. Using an immunoassay as a proof of concept, iron oxide nanoparticles (NPs) captured in the sandwich-type assay system were transformed into a near-infrared (NIR) laser-driven photothermal agent, Prussian blue (PB) NPs, which acted as a photothermal probe to convert the assay signal into heat through the photothermal effect, thus allowing sensitive biomolecular quantitation using a thermometer. This is the first report of biomolecular quantitation using a thermometer and also serves as the first attempt to introduce the nanoparticle-mediated photothermal effect for bioassays.

References

Mar 10, 2011·Angewandte Chemie·Weisi QuXingyu Jiang
Apr 16, 2011·Nano Letters·Constantin UngureanuTon G van Leeuwen
May 14, 2011·Advanced Materials·Luc GervaisEmmanuel Delamarche
Mar 31, 2012·Science Translational Medicine·John R PrensnerArul M Chinnaiyan
Oct 24, 2012·Chemical Communications : Chem Comm·Guanglei FuXiuli Yue
Mar 13, 2013·Journal of the American Chemical Society·Hashem Akhavan-TaftiWenhua Xie
Mar 27, 2013·Nanoscale·Jiasi Wang, Xiaogang Qu
Feb 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrew D WarrenSangeeta N Bhatia
Jul 18, 2014·Nanoscale·D JaqueJ García Solé
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Xiao-Da LiZhi-Fei Dai

❮ Previous
Next ❯

Citations

Mar 3, 2018·The Analyst·Dan LiuChaoyong Yang
Jun 17, 2016·Chemical Communications : Chem Comm·Tianhai JiDong Wang
Aug 18, 2020·Beilstein Journal of Nanotechnology·Mykola BorzenkovGiuseppe Chirico
Oct 1, 2020·Sensors·Clara Abardía-SerranoMaría Jesús Lobo-Castañón
Dec 13, 2017·ACS Applied Materials & Interfaces·Sai Krishna KatlaXiuJun Li
Nov 10, 2018·Analytical Chemistry·Yanling SongChaoyong Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.