Nanoparticle-mediated targeted delivery of antiretrovirals to the brain

Methods in Enzymology
Supriya D MahajanStanley A Schwartz

Abstract

Nanotechnology offers a new platform for therapeutic delivery of antiretrovirals to the central nervous system (CNS) where human immunodeficiency virus (HIV-1) is sequestered in patients with HIV-1-associated neurological disorders (HAND). HAND is a spectrum of neurocognitive disorders that continue to persist in HIV-1-infected patients in spite of successful highly active antiretroviral therapy (HAART). Nanoformulated antiretroviral drugs offer multifunctionality, that is, the ability to package multiple diagnostic and therapeutic agents within the same nanocomposite, along with the added provisions of site-directed delivery, delivery across the blood-brain barrier (BBB), and controlled release of therapeutics. We have stably incorporated the antiretroviral drug, Amprenavir, within a transferrin (Tf)-conjugated quantum dot (QD), and evaluated the transversing ability of this Tf-QD-Amprenavir nanoplex across an in vitro BBB model and analyzed its antiviral efficacy in HIV-1-infected monocytes. We describe methods for synthesis of the Tf-QD-Amprenavir nanoplex and approaches to evaluate both its BBB transversing capability and antiviral efficacy.

Citations

Oct 12, 2012·International Journal of Nanomedicine·Supriya D MahajanStanley A Schwartz
Apr 18, 2014·International Journal of Nanomedicine·Maria João GomesBruno Sarmento
Jul 16, 2013·Expert Opinion on Drug Discovery·Amrit S BoeseStephanie A Booth
Apr 25, 2018·Proteomics. Clinical Applications·Collins CheruiyotMing Li
Nov 9, 2012·Small·Daniela GuarnieriPaolo A Netti
Aug 2, 2018·Bioengineering & Translational Medicine·Maya MonroeHonggang Cui
Nov 9, 2019·Current Pharmaceutical Design·Tatiana Rita de Lima NascimentoLúcio Roberto Cançado Castellano
Oct 1, 2018·Advanced Therapeutics·Burcin YavuzDavid L Kaplan
Sep 5, 2017·Journal of Drug Targeting·Nila Mary VargheseShailendra K Saxena
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana Flavia BurlecMonica Hăncianu

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