Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

Nanotheranostics
Saborni ChattopadhyayChe-Ming Jack Hu

Abstract

Synthetic nanoparticles play an increasingly significant role in vaccine design and development as many nanoparticle vaccines show improved safety and efficacy over conventional formulations. These nanoformulations are structurally similar to viruses, which are nanoscale pathogenic organisms that have served as a key selective pressure driving the evolution of our immune system. As a result, mechanisms behind the benefits of nanoparticle vaccines can often find analogue to the interaction dynamics between the immune system and viruses. This review covers the advances in vaccine nanotechnology with a perspective on the advantages of virus mimicry towards immune potentiation. It provides an overview to the different types of nanomaterials utilized for nanoparticle vaccine development, including functionalization strategies that bestow nanoparticles with virus-like features. As understanding of human immunity and vaccine mechanisms continue to evolve, recognizing the fundamental semblance between synthetic nanoparticles and viruses may offer an explanation for the superiority of nanoparticle vaccines over conventional vaccines and may spur new design rationales for future vaccine research. These nanoformulations are poised to prov...Continue Reading

Citations

Mar 7, 2018·Advanced Healthcare Materials·Leon Chien-Wei LinChe-Ming Jack Hu
Oct 17, 2019·Pharmaceutics·Veena VijayanIn-Kyu Park
May 10, 2018·Nanoscale Research Letters·Michael Zhao, Mingyao Liu
Feb 9, 2019·Frontiers in Immunology·Soultan Al-HalifaDenis Archambault
Jan 3, 2019·Biomaterials Science·Suresh Kumar GullaArabinda Chaudhuri
Mar 13, 2019·Frontiers in Oncology·Dwain G van ZylHenri-Jacques Delecluse
May 22, 2020·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Xinyue HuangHelen E Townley
Jun 30, 2019·Advanced Materials·C Wyatt ShieldsSamir Mitragotri
Jul 26, 2019·Polymers·Raimundo Lopes da SilvaRoseane Maria Ribeiro Costa
Nov 10, 2020·Expert Review of Anti-infective Therapy·Mahendra RaiAvinash P Ingle
Aug 14, 2020·Molecular Pharmaceutics·Zachary R SiaJonathan F Lovell
Dec 2, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stefanie ThalhauserMiriam Breunig
Dec 22, 2020·Future Virology·Laura M Stephens, Steven M Varga
Jan 8, 2021·Frontiers in Chemistry·Neelam ThakurParames C Sil
Oct 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara Maslanka FigueroaAchim Goepferich
Mar 7, 2021·International Journal of Molecular Sciences·Que Dan NguyenTakafumi Ueno
Feb 23, 2021·Emergent Materials·Farzan Vahedifard, Krishnan Chakravarthy
Apr 27, 2021·Molecular Therapy. Methods & Clinical Development·Pin-Hung LinHung-Chih Yang
May 30, 2021·Proceedings of the National Academy of Sciences of the United States of America·Zachary R SiaJonathan F Lovell
Jun 22, 2021·Frontiers in Pharmacology·Seyed Davoud JazayeriChit Laa Poh
Oct 18, 2019·Bioconjugate Chemistry·Sathi RoyWolfgang J Parak
Feb 28, 2018·Bioconjugate Chemistry·Rui KuaiJames J Moon
Aug 28, 2021·International Journal of Molecular Sciences·Sofía Mirón-BarrosoSonia Trigueros
Oct 10, 2020·ACS Nano·Young Hun ChungNicole F Steinmetz
Sep 14, 2021·Frontiers in Immunology·Gregory P HowardRhoel R Dinglasan
Sep 10, 2020·Nano Today·Marcel Alexander HeinrichJai Prakash
Oct 30, 2021·Journal of Medical Virology·Luigi CattelFrancesco Cattel
Dec 20, 2021·Seminars in Immunology·Savannah E Est-WitteJonathan P Schneck

❮ Previous
Next ❯

Methods Mentioned

BETA
nanoprecipitation
antigen display

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Microbiology
Shelley Segal, Adrian V S Hill
Vaccine
Liang ZhaoAnton P J Middelberg
Journal of Controlled Release : Official Journal of the Controlled Release Society
Gourapura J RenukaradhyaSurya K Mallapragada
© 2022 Meta ULC. All rights reserved