Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies

Vaccines
Mitch Brinkkemper, Kwinten Sliepen

Abstract

The enormous sequence diversity between human immunodeficiency virus type 1 (HIV-1) strains poses a major roadblock for generating a broadly protective vaccine. Many experimental HIV-1 vaccine efforts are therefore aimed at eliciting broadly neutralizing antibodies (bNAbs) that are capable of neutralizing the majority of circulating HIV-1 strains. The envelope glycoprotein (Env) trimer on the viral membrane is the sole target of bNAbs and the key component of vaccination approaches aimed at eliciting bNAbs. Multimeric presentation of Env on nanoparticles often plays a critical role in these strategies. Here, we will discuss the different aspects of nanoparticles in Env vaccination, including recent insights in immunological processes underlying their perceived advantages, the different nanoparticle platforms and the various immunogenicity studies that employed nanoparticles to improve (neutralizing) antibody responses against Env.

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Citations

Jan 30, 2020·Vaccines·Ursula Dietrich
Dec 4, 2019·Expert Review of Vaccines·Iván Del Moral-Sánchez, Kwinten Sliepen
Apr 25, 2020·Frontiers in Bioengineering and Biotechnology·Phindile XimbaEdward P Rybicki
Dec 2, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stefanie ThalhauserMiriam Breunig
Apr 10, 2020·Cell Host & Microbe·P J KlasseJohn P Moore
Sep 11, 2020·Accounts of Chemical Research·Yong ChenBruno G De Geest
Oct 24, 2021·International Journal of Pharmaceutics·Maria TsakiriCostas Demetzos
Nov 23, 2021·Journal of the International AIDS Society·Ronald Derking, Rogier W Sanders

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Methods Mentioned

BETA
fluorescence-activated cell sorting
transgenic

Clinical Trials Mentioned

NCT03547245

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