Nanoparticles as computed tomography contrast agents: current status and future perspectives

Nanomedicine
Malka ShiloRachela Popovtzer

Abstract

The importance of computed tomography (CT) as one of the leading radiology technologies applied in the field of biomedical imaging escalated the development of nanoparticles as the next generation CT contrast agents. Nanoparticles are expected to play a major role in the future of medical diagnostics due to their many advantages over the conventional contrast agents, such as prolonged blood circulation time, controlled biological clearance pathways and specific molecular targeting capabilities. This paper will describe the basic design principles of nanoparticle-based CT contrast agents and review the state-of-the-art developments and clinical applications of blood pool, passive and active targeting CT contrast agents.

References

Sep 5, 1989·The American Journal of Cardiology·G L Wolf
Nov 1, 1993·Investigative Radiology·W KrauseG Schuhmann-Giampieri
Jun 3, 1999·Investigative Radiology·J PeterseinB Hamm
Dec 26, 2001·Chemical Reviews·S B Yu, A D Watson
Oct 9, 2002·Angewandte Chemie·Andrea Schroedter, Horst Weller
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Jan 21, 2006·AJR. American Journal of Roentgenology·Srinivasan MukundanAnanth Annapragada
Feb 25, 2006·The British Journal of Radiology·J F HainfeldH M Smilowitz
Nov 23, 2006·Advanced Drug Delivery Reviews·Claire CorotMarc Port
Jun 7, 2007·Pharmaceutical Research·Birgit RombergGert Storm
Jul 24, 2007·Biomaterials·Anna GalperinShlomo Margel
Feb 22, 2008·Nature·Javier Sanz, Zahi A Fayad
Jun 17, 2008·Advanced Drug Delivery Reviews·Partha GhoshVincent M Rotello
Jul 10, 2008·Molecular Pharmaceutics·Shyh-Dar Li, Leaf Huang
Dec 17, 2008·Chemistry of Materials : a Publication of the American Chemical Society·Chenjie XuShouheng Sun
Apr 16, 2009·Cancer Research·Geoffrey von MaltzahnSangeeta N Bhatia
Apr 16, 2009·Nano Letters·Rachela PopovtzerRaoul Kopelman
Nov 11, 2009·Chemistry : a European Journal·In-Cheol SunCheol-Hee Ahn
Dec 17, 2009·International Journal of Nanomedicine·Ehsan SameiSrinivasan Mukundan
Feb 16, 2010·Biochemical and Biophysical Research Communications·C Lasagna-ReevesC Soto
Feb 17, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·R A Sperling, W J Parak
Mar 30, 2010·Expert Opinion on Drug Delivery·Claire M CobleyYounan Xia
Apr 3, 2010·Current Drug Metabolism·Jianqiu WangWeimin Fan
Apr 20, 2010·Angewandte Chemie·David A GiljohannChad A Mirkin
Apr 23, 2010·Expert Opinion on Drug Delivery·Rochelle ArvizoPriyabrata Mukherjee
Apr 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nripen ChandaRaghuraman Kannan
Apr 29, 2010·Current Oncology Reports·Ivan H El-Sayed
May 4, 2010·Biochimica Et Biophysica Acta·Andrea KunzmannBengt Fadeel

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Citations

Nov 16, 2012·International Journal of Nanomedicine·Jonathan LelloucheEhud Banin
Sep 26, 2013·Advanced Drug Delivery Reviews·Timon Hussain, Quyen T Nguyen
Jun 3, 2014·Journal of Translational Medicine·Marco OrecchioniLucia Gemma Delogu
Nov 22, 2014·Nanomedicine·Giuseppe VisaniAlessandro Isidori
Oct 25, 2014·Nanomedicine·Rinat MeirRachela Popovtzer
Jun 9, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lei Xi, Hubei Jiang
Feb 25, 2015·Scientific Reports·Md Wasi AhmadGang Ho Lee
Apr 5, 2013·Advanced Materials·Nohyun LeeTaeghwan Hyeon
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Avnesh S Thakor, Sanjiv S Gambhir
Jan 29, 2014·Contrast Media & Molecular Imaging·Dipanjan PanGregory M Lanza
Jan 29, 2014·Contrast Media & Molecular Imaging·Taeyjuana CurryRachela Popovtzer
Mar 19, 2016·Contrast Media & Molecular Imaging·Julia G MannheimBernd J Pichler
Apr 29, 2014·Biomaterials·Erlei Jin, Zheng-Rong Lu
Jun 29, 2012·Journal of Drug Targeting·Wei Li Lee, Say Chye Joachim Loo
Mar 31, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Pazit Polak, Orit Shefi
May 27, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Ji-Tao SongYuan-Di Zhao
Mar 20, 2015·Drug Delivery and Translational Research·James T Cole, Nolan B Holland
Jan 24, 2015·Journal of Biotechnology·Mohan C M ArachchigeOleg A Andreev
Feb 25, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Piersandro PallaviciniAngelo Taglietti
Jan 21, 2015·Nanomedicine·Lisa E ColeRyan K Roeder
May 8, 2016·Journal of Materials Science. Materials in Medicine·Jan ZidekJozef Kaiser
Oct 12, 2016·BioMed Research International·Ho Won LeeByeong-Cheol Ahn
Jan 4, 2017·Chemical Reviews·Bryan Ronain Smith, Sanjiv Sam Gambhir
May 26, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rinat Meir, Rachela Popovtzer
May 16, 2015·Organic & Biomolecular Chemistry·Stefanie PapstDavid E Williams
Aug 23, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Darya V EvtushokMichael A Shestopalov

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Methods Mentioned

BETA
acetylation
dissection
fluorescence imaging

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