Nanoparticles as contrast agents for the diagnosis of Alzheimer's disease: a systematic review.

Nanomedicine
Marina UlanovaNady Braidy

Abstract

Nanoparticle (NP)-based magnetic contrast agents have opened the potential for MRI to be used for early diagnosis of Alzheimer's disease (AD). This article aims to review the current progress of research in this field. A comprehensive literature search was performed based on PubMed, Medline, EMBASE, PsychINFO and Scopus databases using the following terms: 'Alzheimer's disease' AND 'nanoparticles' AND 'Magnetic Resonance Imaging.' 33 studies were included that described the development and utility of various NPs for AD imaging, including their coating, functionalization, MRI relaxivity, toxicity and bioavailability. NPs show immense promise for neuroimaging, due to superior relaxivity and biocompatibility compared with currently available imaging agents. Consistent reporting is imperative for further progress in this field.

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Citations

Jan 15, 2021·Nanomedicine·Alice Bough
Jan 20, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lingxiao ZhangDaishun Ling
Nov 17, 2020·Current Opinion in Psychiatry·Nady BraidyPerminder S Sachdev

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