Nanoparticles as image enhancing agents for ultrasonography

Physics in Medicine and Biology
Jun LiuThomas J Rosol

Abstract

Nanoparticles have drawn great attention as targeted imaging and/or therapeutic agents. The small size of the nanoparticles allows them to target cells that are beyond capillary vasculature, such as cancer cells. We investigated the effect of solid nanoparticles for enhancing ultrasonic grey scale images in tissue phantoms and mouse livers in vivo. Silica nanospheres (100 nm) were dispersed in agarose at 1-2.5% mass concentration and imaged by a high-resolution ultrasound imaging system (transducer centre frequency: 30 MHz). Polystyrene particles of different sizes (500-3000 nm) and concentrations (0.13-0.75% mass) were similarly dispersed in agarose and imaged. Mice were injected intravenously with nanoparticle suspensions in saline. B-mode images of the livers were acquired at different time points after particle injection. An automated computer program was used to quantify the grey scale changes. Ultrasonic reflections were observed from nanoparticle suspensions in agarose gels. The image brightness, i.e., mean grey scale level, increased with particle size and concentration. The mean grey scale of mouse livers also increased following particle administration. These results indicated that it is feasible to use solid nanopart...Continue Reading

References

Sep 1, 1987·Ultrasound in Medicine & Biology·K J ParkerM R Violante
Jan 1, 1997·Ultrasound in Medicine & Biology·G M LanzaS A Wickline
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S A AndersonJ J Kotyk
Sep 3, 2002·Advanced Drug Delivery Reviews·Irène BriggerPatrick Couvreur
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Paul A Dayton, Katherine W Ferrara
Oct 7, 2003·Annual Review of Biomedical Engineering·Jennifer L West, Naomi J Halas
Mar 12, 2004·Physics in Medicine and Biology·Simon R Cherry
May 26, 2004·Cardiology Clinics·Flordeliza S VillanuevaJagat Narula

❮ Previous
Next ❯

Citations

Oct 7, 2010·Analytical and Bioanalytical Chemistry·Megan A HahnBrij M Moudgil
Oct 8, 2008·Nature Nanotechnology·Virendra K ParasharMartin A M Gijs
Mar 22, 2013·Science Translational Medicine·Jesse V JokerstSanjiv S Gambhir
Feb 22, 2008·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·K K Jain
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Renu JohnStephen A Boppart
Jun 15, 2010·Clinical Radiology·N DeshpandeJ K Willmann
Sep 22, 2009·Surgery·Maria K SchwartzVirginia M Miller
Sep 29, 2009·International Journal of Pharmaceutics·Ye WangYuhong Xu
Mar 14, 2012·International Journal of Cancer. Journal International Du Cancer·Pericles PericleousEfstathios P Efstathopoulos
Apr 23, 2009·Molecular Oncology·Leonard Fass
Jan 4, 2017·Chemical Reviews·Bryan Ronain Smith, Sanjiv Sam Gambhir
Nov 5, 2014·Surface Science Reports·Alexander LibermanAndrew C Kummel
Nov 20, 2014·Chemical Society Reviews·Claudia CaltagironeRiccardo Montis
Sep 20, 2007·Technology in Cancer Research & Treatment·John C RoeskeRalph R Weichselbaum
Sep 29, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Johann Le Floc'hF Stuart Foster
Jul 30, 2014·World Journal of Radiology·Marco Di PaolaSergio Casciaro
Mar 19, 2014·Nature Nanotechnology·Mikhail G ShapiroSteven M Conolly
Aug 3, 2007·Physics in Medicine and Biology·Jun LiuJeffrey L Voorhees
Jan 1, 2016·Nanomaterials·Francesco ConversanoSergio Casciaro
Oct 16, 2008·Physics in Medicine and Biology·Fang YangNing Gu
May 10, 2017·Physiological Measurement·Richard BayfordScarlet Xiaoyan Wang
Feb 1, 2018·Biomacromolecules·Parasmani PageniChuanbing Tang
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Fei LiFei Yan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.