Nanoparticles as potential new generation broad spectrum antimicrobial agents

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Clarence S Yah, Geoffrey S Simate

Abstract

The rapid emergence of antimicrobial resistant strains to conventional antimicrobial agents has complicated and prolonged infection treatment and increased mortality risk globally. Furthermore, some of the conventional antimicrobial agents are unable to cross certain cell membranes thus, restricting treatment of intracellular pathogens. Therefore, the disease-causing-organisms tend to persist in these cells. However, the emergence of nanoparticle (NP) technology has come with the promising broad spectrum NP-antimicrobial agents due to their vast physiochemical and functionalization properties. In fact, NP-antimicrobial agents are able to unlock the restrictions experienced by conventional antimicrobial agents. This review discusses the status quo of NP-antimicrobial agents as potent broad spectrum antimicrobial agents, sterilization and wound healing agents, and sustained inhibitors of intracellular pathogens. Indeed, the perspective of developing potent NP-antimicrobial agents that carry multiple-functionality will revolutionize clinical medicine and play a significant role in alleviating disease burden.

References

Jan 9, 1999·Clinical Microbiology Reviews·G McDonnell, A D Russell
Jul 14, 1999·Journal of Medical Microbiology·A D RussellJ Y Maillard
Jan 5, 2002·Obstetrics and Gynecology·F D MaloneM E Dalton
Aug 14, 2003·Journal of Virology·Martha F KramerDonald M Coen
Aug 16, 2005·The Journal of Hospital Infection·Y LiE Newton
Oct 13, 2005·Chemical Communications : Chem Comm·Raymond Wai-Yin SunChi-Ming Che
Apr 1, 2006·BMJ : British Medical Journal·Vanessa JonesKeith G Harding
Apr 7, 2006·The Journal of Antimicrobial Chemotherapy·Rajesh Pandey, G K Khuller
Oct 20, 2006·Bioorganic & Medicinal Chemistry Letters·Edward TurosDaniel V Lim
Nov 1, 2006·ChemMedChem·Jun TianPaul K H Tam
May 23, 2007·Expert Opinion on Pharmacotherapy·Douglas S Kwon, Eleftherios Mylonakis
Jul 27, 2007·International Wound Journal·Joseph J CastellanoMartin C Robson
Dec 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elsa BrionesJosé M Lanao
Sep 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marin H Kollef
Apr 4, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Seyhan BoyogluShree R Singh
Apr 21, 2009·Antiviral Chemistry & Chemotherapy·Anita B GargJoseph Romano
Oct 6, 2009·Journal of Materials Science. Materials in Medicine·K MadhumathiR Jayakumar
Nov 17, 2009·Advanced Drug Delivery Reviews·Nereide Stela Santos-Magalhães, Vanessa Carla Furtado Mosqueira
Dec 1, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Subash Chandra MohapatraShyam Singh Chauhan
Dec 18, 2009·Current Medicinal Chemistry·L ZhangC-M Huang
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Edurne ImbuluzquetaMaria J Blanco-Prieto
Feb 11, 2010·Journal of Nanobiotechnology·Humberto H LaraCristina Rodriguez-Padilla
Aug 20, 2010·Journal of Nanobiotechnology·Janice L SpeshockSaber M Hussain
Jan 29, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Karen H L KwanKenneth K Y Wong
Feb 8, 2011·Applied and Environmental Microbiology·Yanping XieXianming Shi
Mar 15, 2011·Bioorganic & Medicinal Chemistry Letters·Gabriel Navarrete-VazquezEmanuel Hernández-Nuñez
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hans-Heinrich HoffmannMegan L Shaw
Jun 8, 2011·Parasitology Research·Namita Soni, Soam Prakash
Jul 2, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Fidel Martínez-GutierrezHoracio Bach
Sep 13, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Jyh-Gang LeuYao-Jen Liang
Oct 1, 2011·Drug Development and Industrial Pharmacy·Shadabul HaqueSanjula Baboota
Oct 21, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Salim IsmailMichael Wilson
Oct 26, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stefania GaldieroMassimiliano Galdiero
Nov 25, 2011·International Journal of Nanomedicine·Adil M AllahverdiyevMiriam Rafailovich
Jun 2, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·L ChoncoM A Muñoz-Fernández
Jul 7, 2012·Colloids and Surfaces. B, Biointerfaces·Gururaj M NeelgundZhiping Luo

❮ Previous
Next ❯

Citations

Aug 21, 2016·The Science of the Total Environment·Chiqian ZhangShashikanth Gajaraj
Jan 24, 2018·Frontiers in Veterinary Science·Chetan SharmaHarsh Panwar
Jul 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eva Torres-SangiaoMonica Cartelle Gestal
Feb 11, 2020·Drug Delivery·Samah Attia AlgharibShuyu Xie
May 4, 2018·The Journal of Microbiology·Rout George KerryJayanta Kumar Patra
Sep 23, 2018·Biointerphases·Victoria le Ching TanKate Fox
Oct 19, 2019·IET Nanobiotechnology·Debalina BhattacharyaMainak Mukhopadhyay
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Brenda KischkelCarlos P Taborda
Feb 26, 2019·Folia Parasitologica·Oluyomi Stephen AdeyemiKentaro Kato
Mar 29, 2018·Applied Microbiology and Biotechnology·Muhammad OvaisZabta Khan Shinwari
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sharafaldin Al-MusawiHumaira Rizwana
Apr 24, 2021·Scientific Reports·Sui-Yuan ChangPan-Chyr Yang
May 1, 2021·International Journal of Molecular Sciences·Maria QuitérioCatarina Pinto Reis
Jan 12, 2021·Critical Reviews in Food Science and Nutrition·Yu TianZhouli Wang
Jun 26, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Nour K YounisAli H Eid
Aug 8, 2021·Nanomaterials·Yulia GorshkovaEwa Juszyńska-Gałązka

❮ Previous
Next ❯

Methods Mentioned

BETA
Infrared Spectroscopy
X-ray
AFM

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Campylobacteriosis (ASM)

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Related Papers

Journal of Rehabilitation
M D Hightower
Medizinische Monatsschrift für Pharmazeuten
Janine Diehl, Alexander Kurz
© 2021 Meta ULC. All rights reserved