Nanoparticles based on carboxymethylcellulose-modified rice protein for efficient delivery of lutein

Food & Function
Yu XuXue-Mei Zhu

Abstract

Lutein, as a natural nutrient, has many benefits for human health. However, its poor chemical stability and low bioavailability limit the application of lutein in foods. The aim of this study is to design and develop rice protease hydrolysate (RPH)-carboxymethylcellulose (CMC) nanocarriers for efficient delivery of lutein. RPH-CMC nanoparticles were prepared by heating at a ratio of RPH to CMC of 4 : 1 and pH of 6.0 (70 °C, 20 min). The structure of the nanoparticles was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM). In addition, the stability, in vitro release characteristics, anti-proliferation and drug absorption of lutein-loaded rice protein nanoparticles (Lut-R) and lutein-loaded CMC-RPH nanoparticles (Lut-R-C) were evaluated. The results of in vitro release showed that compared with Lut-R, Lut-R-C could effectively slow down the release of lutein in the stomach (19.55 ± 1.71% and 8.10 ± 0.41%) and accelerate its release after entering the small intestine (76.64 ± 1.47% and 96.07 ± 0.71%). In addition, RPH-CMC nanoparticles had good biocompatibility, and Lut-R-C nanoparticles could effectively inhibit the proliferation of breast cancer c...Continue Reading

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Citations

Jan 6, 2021·Critical Reviews in Food Science and Nutrition·Saeid MaghsoudiThomas J Webster

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Methods Mentioned

BETA
dynamic light scattering
transmission electron microscopy
infrared spectroscopy
X-ray

Software Mentioned

SPSS statistics
Graph Pad Prism
Origin

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