Nanoparticles disguised as red blood cells to evade the immune system

Expert Opinion on Biological Therapy
Ronnie H FangLiangfang Zhang

Abstract

The development of nanoparticle platforms with long in vivo circulation half-life has long been one of the major goals in the field of cancer drug delivery. Long-circulating nanoparticles can more effectively localize to the tumor site through either passive or active targeting mechanisms. The current gold standard for bestowing long-circulating attributes involves the use of PEG, which surrounds the particles with a hydration layer and thereby prevents recognition by the mononuclear phagocyte system. Recently, a new strategy for synthesizing biomimetic nanoparticles has been inspired by the body's own long-circulating entities, red blood cells (RBCs). Such a system disguises drug nanocarriers as 'self' using membrane materials directly derived from RBCs. This method has been demonstrated to prolong particle systemic circulation half-life beyond that of the corresponding PEGylated systems. The RBC membrane-coated nanoparticles present a major breakthrough in drug delivery technology and show great promise for clinical applications. Herein we highlight the significance and the unique features of this nature-inspired nanoparticle platform and offer opinions on its future prospects.

References

Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L S ZalmanH J Müller-Eberhard
Jun 17, 2000·Science·P A OldenborgF P Lindberg
Mar 4, 2003·Nature Reviews. Drug Discovery·J Milton Harris, Robert B Chess
Oct 26, 2005·Drug Discovery Today·Francesco M Veronese, Gianfranco Pasut
Oct 31, 2006·Advanced Drug Delivery Reviews·Omid C Farokhzad, Robert Langer
Oct 25, 2007·Clinical Pharmacology and Therapeutics·L ZhangO C Farokhzad
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nishit DoshiSamir Mitragotri
Mar 3, 2010·Expert Opinion on Drug Delivery·Vladimir R Muzykantov
Jul 22, 2010·Angewandte Chemie·Katrin KnopUlrich S Schubert
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Timothy J MerkelJoseph M DeSimone
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Che-Ming J HuLiangfang Zhang

❮ Previous
Next ❯

Citations

Jun 10, 2014·Expert Opinion on Drug Delivery·Manisha BhateriaRabi Sankar Bhatta
Feb 24, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Gamaleldin I HarisaSabry M Attia
Dec 15, 2015·Macromolecular Bioscience·Paula PereiraFrancisco M Gama
Apr 11, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Moritz Beck-BroichsitterPatrick Couvreur
Nov 12, 2013·Trends in Biotechnology·Gavin T NobleBasar Bilgicer
Dec 9, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Paula PereiraFrancisco M Gama
May 6, 2016·Annual Review of Chemical and Biomolecular Engineering·Ronnie H Fang, Liangfang Zhang
Jan 22, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seok-Beom YongYong-Hee Kim
Jul 14, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Gamaleldin I HarisaSabry M Attia
Mar 23, 2018·Biomaterials Science·Gella Maelys Ngandeu NeubiYang Ding
Mar 28, 2018·Advanced Materials·Ronnie H FangLiangfang Zhang
Mar 12, 2019·Advanced Healthcare Materials·Qingxin MuMiqin Zhang
Jun 18, 2019·Advanced Materials·Jiarong ZhouLiangfang Zhang
Jul 3, 2019·Current Pharmaceutical Design·Adrian Rodríguez-CarlosBruno Rivas-Santiago
Jan 30, 2020·Biomaterials Science·Qasim MuhammadHansoo Park
Jan 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sheng WangLiangzhu Feng
Jul 24, 2020·Journal of Microencapsulation·Jinyan ShiLijiang Chen
May 9, 2013·Chemical Communications : Chem Comm·Thanh Duc MaiJean-Michel Siaugue
Oct 22, 2017·Journal of Biomedical Materials Research. Part a·Volker EtteltMichael Veith
May 27, 2016·Bioengineering & Translational Medicine·Diana DehainiLiangfang Zhang
Aug 6, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaobao XuYuanpei Li
Apr 11, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Ayomi S Perera, Marc-Olivier Coppens
Nov 16, 2019·Advanced Biosystems·Ashley V KrollLiangfang Zhang
Aug 21, 2019·Journal of Biomedical Optics·Taylor HanleyBahman Anvari
Jan 8, 2013·Nanoscale·Songwei TanZhiping Zhang
Mar 7, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Joon Ho ParkLiangfang Zhang
Feb 1, 2020·Acta Biomaterialia·Cheng-Hui XuCui-Yun Yu
Dec 31, 2020·International Journal of Molecular Sciences·Kiruphagaran ThangarajuPaul W Buehler
Mar 16, 2017·Biomaterials·Ronnie H FangLiangfang Zhang
Sep 19, 2020·Advanced Drug Delivery Reviews·Flávia CastroBruno Sarmento
May 7, 2021·Journal of Immunotoxicology·Leonor de BragancaJeremy P Derrick
May 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zahid HussainMohammed A S Abourehab

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Che-Ming J HuLiangfang Zhang
Current Opinion in Biotechnology
Carmen Alvarez-Lorenzo, Angel Concheiro
International Journal of Pharmaceutics
Kentaro FurumotoToshikiro Kimura
Nanomedicine : Nanotechnology, Biology, and Medicine
Longzhu PiaoRobert J Lee
© 2022 Meta ULC. All rights reserved