Nanoparticles in Targeted Alpha Therapy

Nanomaterials
Agnieszka Majkowska-PilipAleksander Bilewicz

Abstract

Recent advances in the field of nanotechnology application in nuclear medicine offer the promise of better therapeutic options. In recent years, increasing efforts have been made on developing nanoconstructs that can be used as carriers for immobilising alpha (α)-emitters in targeted drug delivery. In this publication, we provide a comprehensive overview of available information on functional nanomaterials for targeted alpha therapy. The first section describes why nanoconstructs are used for the synthesis of α-emitting radiopharmaceuticals. Next, we present the synthesis and summarise the recent studies demonstrating therapeutic applications of α-emitting labelled radiobioconjugates in targeted therapy. Finally, future prospects and the emerging possibility of therapeutic application of radiolabelled nanomaterials are discussed.

References

May 8, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Gjermund HenriksenRoy H Larsen
Apr 20, 2004·Nuclear Medicine and Biology·Gjermund HenriksenR H Larsen
Apr 28, 2004·Current Opinion in Genetics & Development·Muhammad Al-HajjMichael F Clarke
Jun 3, 2005·Cancer Research·Jaspreet Singh JaggiDavid A Scheinberg
Sep 13, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jan KuckaOndrej Lebeda
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ravi SinghKostas Kostarelos
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Max S Wicha
Mar 31, 2007·Journal of the American Chemical Society·Michael D DienerSaed Mirzadeh
Oct 9, 2007·Nuclear Medicine and Biology·Michael R ZalutskyDarell D Bigner
Oct 16, 2007·Bioconjugate Chemistry·Stavroula SofouGeorge Sgouros
Dec 14, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael R ZalutskyDarell D Bigner
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthias MiedererMarkus Essler
Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Håkan AnderssonRagnar Hultborn
Jun 23, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Andrei IagaruMichael L Goris
Oct 20, 2009·European Journal of Pharmacology·Frederic ZollerWalter Mier
Nov 3, 2010·International Journal of Nanomedicine·Alessandro RuggieroMichael R McDevitt
Feb 12, 2011·Carcinogenesis·Fares Al-EjehKum Kum Khanna
Mar 8, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Kwon Yong, Martin W Brechbiel
Mar 26, 2011·Bioconjugate Chemistry·Jonathan WoodwardSaed Mirzadeh
Jul 20, 2011·Physical Chemistry Chemical Physics : PCCP·Julie ChampionNicolas Galland
Mar 13, 2012·International Journal of Medical Sciences·Rajamanickam BaskarKheng-Wei Yeoh
Jun 28, 2012·Molecular Pharmaceutics·Niladri ChattopadhyayRaymond M Reilly
Dec 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwamena E BaidooMartin W Brechbiel
Feb 26, 2013·Current Pharmaceutical Design·Zilin YuPhilip H Elsinga
Apr 17, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Marta de Souza AlbernazRalph Santos-Oliveira
Oct 1, 2013·Nature Nanotechnology·J Justin MulveyDavid A Scheinberg
Oct 10, 2013·Cancer Biotherapy & Radiopharmaceuticals·Mark F McLaughlinStephen J Kennel
Dec 7, 2013·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Agata PiotrowskaAleksander Bilewicz
Dec 18, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Amey BandekarStavroula Sofou
Jan 1, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·G WangA G Denkova
May 2, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael L MatsonLon J Wilson
Jun 13, 2015·Pharmaceuticals·Robin M de KruijffAntonia G Denkova
Feb 6, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Simmyung YookRaymond M Reilly
Jul 30, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Michelle SempkowskiStavroula Sofou

❮ Previous
Next ❯

Methods Mentioned

BETA
γ-ray spectroscopy
acylation
xenograft

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Nuclear Medicine and Molecular Imaging
A Paden KingFreddy E Escorcia
© 2021 Meta ULC. All rights reserved