Nanoparticles of cationic amphiphilic cyclodextrins entangling anionic porphyrins as carrier-sensitizer system in photodynamic cancer therapy

Biomaterials
Salvatore SortinoMaria Teresa Sciortino

Abstract

The photodynamic activity of a carrier-sensitizer system consisting of heterotopic colloidal nanoparticles (diameter 100-1000 nm) of a cationic amphiphilic cyclodextrin, heptakis(2-omega-amino-O-oligo(ethylene oxide)-6-hexylthio)-beta-CD (SC6CDNH2) encapsulating the anionic 5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,23H-porphyrin (TPPS) is investigated by an interdisciplinary approach involving the combination of time-resolved absorption and emission techniques with in vitro studies on cultured tumor cells. In a range of TPPS:SC6CDNH2 molar ratios between 1:10 and 1:50 these nanoparticles preserve the photodynamic properties of the entrapped photoactive agent. In fact, the triplet state of TPPS is efficiently populated, very long-lived and, as a consequence, able to produce singlet oxygen (the essential species for the photodynamic action) with quantum yield comparable to the free TPPS. Photodynamic efficacy of the carrier/sensitizer system is proven by in vitro studies on tumor Hela cells treated with TPPS:SC6CDNH2 at different molar ratio, showing significant cells death upon illumination with visible light.

References

Jan 1, 1992·Photochemistry and Photobiology·B W Henderson, T J Dougherty
Jun 1, 1987·Photochemistry and Photobiology·T J Dougherty
Mar 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·K Woodburn, D Kessel
Nov 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·G Jori
Mar 25, 1999·Photochemistry and Photobiology·B M Aveline, R W Redmond
Mar 29, 2001·The Journal of Pharmacy and Pharmacology·J TailleferJ C Leroux
Jun 2, 2001·Journal of Photochemistry and Photobiology. B, Biology·X DamoiseauM Hoebeke
Dec 26, 2001·Chemical Reviews·H Ali, J E van Lier
Mar 19, 2002·Journal of Photochemistry and Photobiology. B, Biology·Yvette Niamien KonanEric Allémann
Oct 3, 2002·Chemical Society Reviews·Sandra Monti, Salvatore Sortino
Jan 16, 2003·Bioconjugate Chemistry·Nobuhiro NishiyamaKazunori Kataoka
May 15, 2003·Chemical Reviews·Claude Schweitzer, Reinhard Schmidt
May 15, 2003·Angewandte Chemie·Bart Jan RavooGerhard Wenz
Oct 14, 2003·Cell Death and Differentiation·A MastinoS Guglielmino
Apr 5, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Domenico LombardoAntonino Mazzaglia
Jul 21, 2006·The Journal of Physical Chemistry. B·Antonino MazzagliaLuigi Monsù Scolaro

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Citations

Aug 1, 2007·European Biophysics Journal : EBJ·Michel RouxFlorence Djedaïni-Pilard
Aug 9, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Salvatore Sortino
Jul 14, 2011·Chemical Communications : Chem Comm·Antonino MazzagliaMaria Teresa Sciortino
Jan 26, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Greta VarchiBarbara Ventura
Aug 10, 2010·Journal of Ovarian Research·Murali M YallapuSubhash C Chauhan
Jul 27, 2012·Therapeutic Delivery·Patricia CallejaJuan M Irache
May 16, 2013·Advanced Drug Delivery Reviews·Jianxiang Zhang, Peter X Ma
Jun 20, 2014·Chemical Communications : Chem Comm·Leandro M O LourençoJoão P C Tomé
Oct 8, 2014·Therapeutic Delivery·Diana SamarooNaphtali O'Connor
Jul 2, 2014·Nanomedicine·Jaya Raju Lakkakula, Rui Werner Maçedo Krause
Aug 27, 2009·Organic & Biomolecular Chemistry·Jirí MosingerPavel Kubát
Aug 27, 2009·Expert Opinion on Drug Delivery·Erem Bilensoy, A Atilla Hincal
Apr 2, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Monica CamerinDavid A Russell
Oct 16, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristianne J F RijckenCornelus F van Nostrum
Sep 15, 2010·Chemistry, an Asian Journal·Hiroaki OzawaKazuo Nakazato
Jan 4, 2012·Chemistry : a European Journal·Noufal KandothSalvatore Sortino
Feb 11, 2014·Clinical Implant Dentistry and Related Research·Paulo Esteves Pinto FariaLuiz Antonio Salata
Dec 18, 2008·Physical Chemistry Chemical Physics : PCCP·Giacomo Martini, Laura Ciani
Jul 22, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yumiao Zhang, Jonathan F Lovell
Oct 8, 2016·Nanoscale·Kegang LiuPatrick Hunziker
Jun 7, 2018·Anais Da Academia Brasileira De Ciências·Ana T P C GomesJosé A S Cavaleiro
Aug 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amina Ben MihoubSamir Acherar
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana T P C GomesJosé A S Cavaleiro
Dec 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Betânia Mara AlvarengaJosé Dias Corrêa Junior
Jul 24, 2008·Molecular Pharmaceutics·Ayman KhdairJayanth Panyam

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