Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging

The Analyst
Vindya S PereraSongping D Huang

Abstract

Biocompatible nanoparticles of gadolinium-incorporated Prussian blue with the empirical formula K(0.94)Gd(0.02)Fe[Fe(CN)6] exhibit extremely high stability against the release of Gd(3+) and CN(-) ions under the acidic conditions similar to stomach juice. The high r1 relaxivity, low cytotoxicity and the ability of such nanoparticles to penetrate the cell membrane suggest that this coordination-polymer structural platform offers a unique opportunity for developing the next generation of T1-weighted oral cellular MRI probes for the early detection of tumors in the gastrointestinal tract.

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Citations

May 14, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Murthi S KandanapitiyeSongping D Huang
Sep 22, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Neda NaseriYounes Pilehvar-Soltanahmadi
Feb 19, 2019·Chemical Science·Jiacheng LinXuechuan Hong
Nov 24, 2020·International Journal of Nanomedicine·Alaa Yaser DarweshMahasen Mohamed Meshali
Apr 22, 2021·Advanced Healthcare Materials·Gary StinnettVicki L Colvin

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