NANOPARTICLES. Production of amorphous nanoparticles by supersonic spray-drying with a microfluidic nebulator

Science
Esther AmstadD A Weitz

Abstract

Amorphous nanoparticles (a-NPs) have physicochemical properties distinctly different from those of the corresponding bulk crystals; for example, their solubility is much higher. However, many materials have a high propensity to crystallize and are difficult to formulate in an amorphous structure without stabilizers. We fabricated a microfluidic nebulator that can produce amorphous NPs from a wide range of materials, even including pure table salt (NaCl). By using supersonic air flow, the nebulator produces drops that are so small that they dry before crystal nuclei can form. The small size of the resulting spray-dried a-NPs limits the probability of crystal nucleation in any given particle during storage. The kinetic stability of the a-NPs—on the order of months—is advantageous for hydrophobic drug molecules.

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Citations

Jan 19, 2016·International Journal of Pharmaceutics·Chih-Hui YangKeng-Shiang Huang
Oct 28, 2015·Physical Chemistry Chemical Physics : PCCP·Esther AmstadDavid A Weitz
Apr 12, 2016·Biochimica Et Biophysica Acta. General Subjects·J K R WeberS R Byrn
Apr 8, 2016·Chemical Reviews·Tao LiByeongdu Lee
Jun 4, 2016·Scientific Reports·Qiang MengPeichun Amy Tsai
Jul 13, 2016·Advanced Materials·Marta Rubio-MartinezJosep Puigmartí-Luis
Jul 22, 2016·The Journal of Physical Chemistry. B·Esther AmstadDavid A Weitz
Nov 7, 2016·Journal of Pharmaceutical Sciences·Rajan Jog, Diane J Burgess
Mar 16, 2017·Lab on a Chip·Esther AmstadDavid A Weitz
Apr 13, 2017·Environmental Science & Technology·Guanghui YuQirong Shen
May 10, 2017·Lab on a Chip·Dongfei LiuHélder A Santos
Jan 26, 2017·Scientific Reports·Rongshan Qin
Oct 6, 2016·Science Advances·Andrew M J EdwardsGlen McHale
Aug 1, 2019·Angewandte Chemie·Guangze YangChun-Xia Zhao
Aug 1, 2020·Journal of Learning Disabilities·Wilhelmina van DijkSara A Hart
Jun 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Amir A PahlavanRuben Juanes
Feb 2, 2020·Nature Communications·Juraj KnoškaMichael Heymann
Feb 23, 2018·Nature Communications·Xu HouJoanna Aizenberg
Jul 22, 2017·Science·Carlos Macias-RomeroSylvie Roke
Dec 17, 2017·The Journal of Chemical Physics·Bryan R Bzdek, Jonathan P Reid
Feb 23, 2020·Science Advances·M J QaziN Shahidzadeh
Feb 23, 2020·Science Advances·Zenon ToprakciogluTuomas Knowles
Mar 25, 2021·Scientific Reports·Zenon Toprakcioglu, Tuomas P J Knowles
Dec 27, 2018·International Journal of Pharmaceutics·Shukai DingThierry F Vandamme
May 22, 2021·Nature Communications·Manuel CordovaLyndon Emsley
Aug 7, 2021·Life·Andreea CrinteaAlexandra Marioara Craciun
Dec 12, 2017·ACS Nano·Evangelia ZdraliSylvie Roke
Jan 18, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Shukai DingThierry F Vandamme
Dec 7, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Zhengping TanJintao Zhu
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May 26, 2017·Chemical Reviews·Luoran ShangYuanjin Zhao
Sep 29, 2018·Journal of the American Chemical Society·Huachuan DuEsther Amstad

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