Nanoparticles reveal Extreme Size-Sorting and Morphologies in Complex Coacervate Superstructures

Scientific Reports
Jan Bart Ten HoveAldrik H Velders

Abstract

We here provide detailed insight in self-assembled complex coacervate systems exploiting gold nanoparticles for cryoTEM contrast. Nanoparticle-containing dendrimicelles are formed from fifth-generation dendrimer-encapsulated nanoparticles (DENs) and dendrimer-stabilized nanoparticles (DSNs). The complex coacervate structures self-organize in biconcave thin water layers into size-sorted monolayer superstructures. The embedded nanoparticles are a straightforward tool to visualize dendrimicelles and determine the aggregation number and polydispersity. The superstructure shows extreme size-sorting patterns which, contrary to related systems with higher generation dendrimers, consists not only of dendrimicelles but also much bigger complex coacervate nanoassemblies, such as vesicles.

References

Mar 30, 2002·Science·George M Whitesides, Bartosz Grzybowski
Apr 26, 2003·Science·Radoslav SavicDusica Maysinger
Nov 20, 2004·Chemistry : a European Journal·Francesca CorbelliniDavid N Reinhoudt
Nov 29, 2005·Advanced Drug Delivery Reviews·Antony D'Emanuele, David Attwood
Jul 27, 2006·The Journal of Physical Chemistry. B·Robert W J ScottRichard M Crooks
Nov 29, 2008·Advances in Colloid and Interface Science·Ilja K VoetsMartien A Cohen Stuart
Apr 23, 2009·Chemical Society Reviews·Jian-Rong LiHong-Cai Zhou
May 9, 2009·Nature·Ebbe S AndersenJørgen Kjems
Jul 11, 2012·Chemical Society Reviews·Yiyong Mai, Adi Eisenberg
Feb 9, 2013·Chemical Communications : Chem Comm·Junyou WangJasper van der Gucht
Oct 12, 2016·Chemistry : a European Journal·Armando Hernandez-GarciaJunyou Wang
Oct 22, 2016·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Taizo Mori, Torsten Hegmann

❮ Previous
Next ❯

Citations

Aug 15, 2021·Journal of Colloid and Interface Science·Chendan LiJunyou Wang
Jan 8, 2021·ACS Nano·Rebecca KaupAldrik H Velders

❮ Previous
Next ❯

Methods Mentioned

BETA
Dynamic Light Scattering
electron microscopy

Software Mentioned

Matlab
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.