Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies

Cancer Research
Fan ZhangMatthias T Stephan

Abstract

A major obstacle to the success rate of chimeric antigen receptor (CAR-) T-cell therapy against solid tumors is the microenvironment antagonistic to T cells that solid tumors create. Conventional checkpoint blockade can silence lymphocyte antisurvival pathways activated by tumors, but because they are systemic, these treatments disrupt immune homeostasis and induce autoimmune side effects. Thus, new technologies are required to remodel the tumor milieu without causing systemic toxicities. Here, we demonstrate that targeted nanocarriers that deliver a combination of immune-modulatory agents can remove protumor cell populations and simultaneously stimulate antitumor effector cells. We administered repeated infusions of lipid nanoparticles coated with the tumor-targeting peptide iRGD and loaded with a combination of a PI3K inhibitor to inhibit immune-suppressive tumor cells and an α-GalCer agonist of therapeutic T cells to synergistically sway the tumor microenvironment of solid tumors from suppressive to stimulatory. This treatment created a therapeutic window of 2 weeks, enabling tumor-specific CAR-T cells to home to the lesion, undergo robust expansion, and trigger tumor regression. CAR-T cells administered outside this therape...Continue Reading

Citations

Oct 1, 2019·Current Pharmaceutical Design·Alessandra IscaroMunitta Muthana
Aug 7, 2020·Journal of Neuro-oncology·Adam J GrippinElias J Sayour
Sep 27, 2018·International Journal of Molecular Sciences·Elias J SayourDuane A Mitchell
Mar 7, 2021·International Journal of Molecular Sciences·Wan-Tai WuYi-Yen Lee
Apr 10, 2021·Frontiers in Immunology·Preethi Bala Balakrishnan, Elizabeth E Sweeney
Jun 8, 2021·Frontiers in Immunology·Lele MiaoYumin Li
Sep 1, 2021·Biomolecules & Therapeutics·Jinwon ParkYu-Kyoung Oh

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