Nanoparticulate computed tomography contrast agents for blood pool and liver-spleen imaging

Academic Radiology
G S GazelleJ L Toner

Abstract

We investigated the properties of a group of iodine-containing, insoluble compounds formulated as nanoparticles for use as potential blood pool and liver-spleen contrast agents. High-resolution, quantitative computed tomography (CT) was performed prior to and at intervals following the intravenous administration of the contrast agents to rabbits. Time-density characteristics for three organs were evaluated. Excellent enhancement of blood (< or = 232 Hounsfield units [HU]), liver (< or = 263 HU), and spleen (< or = 350 HU) was achieved at the administered dose of 3.0 ml/kg. The composition of the agents influenced the biodistribution, as well as the residence time in blood, and time to peak enhancement in liver. Iodinated nanoparticulate compounds are promising CT contrast agents. Development of agents with desirable pharmacokinetic and biodistribution profiles may permit application-specific contrast enhancement.

References

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Citations

Mar 19, 2002·Advanced Drug Delivery Reviews·Vladimir P Torchilin
Jun 6, 2000·Advanced Drug Delivery Reviews·A A BogdanovR Weissleder
Nov 1, 1996·European Journal of Radiology·P Dawson
Dec 31, 2003·Academic Radiology·Robert F Mattrey, Diego A Aguirre
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Jan 4, 2017·Chemical Reviews·Bryan Ronain Smith, Sanjiv Sam Gambhir
Sep 6, 2003·Optics Letters·Tin Man LeeStephen A Boppart

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