Nanoparticulate mediated transcutaneous immunization: Myth or reality

Nanomedicine : Nanotechnology, Biology, and Medicine
Monika KauravRavi Shankar Pandey

Abstract

Transcutaneous immunization (TCI) is a promising route of vaccine delivery through skin due to many well documented advantages. The main obstacle in TCI is the skin's top dead layer i.e. stratum corneum which is difficult to penetrate. Efficiently delivery of antigen to the immune competent cells of epidermis or dermis in TCI might elicit an effective immune response. In this review, skin immunology with a particular focus on potential of immunological active receptors in influencing adaptive immune responses is highlighted. The challenges with TCI and methods to improve it using different adjuvants, chemical and physical approaches, delivery systems, and combination of above methods to further improve immune response following skin application of antigen are elaborately discussed. Nanoparticulate vaccine delivery systems with reference to their applications in TCI are classified according to their chronological development. Conclusively, clinical translations of above methods are also briefly reviewed. Transcutaneous immunization has been investigated by many as a promising route of vaccination. In this comprehensive review article, the authors described and discussed the existing knowledge and difficulties in this approach. F...Continue Reading

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Citations

Nov 12, 2016·International Journal of Pharmaceutics·Yibang ZhangHuaxi Xu
May 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sónia Alexandra Correia Carabineiro
Oct 12, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Monika KauravRavi Shankar Pandey
Jul 19, 2017·Pharmaceutical Research·M LeoneG Kersten
Aug 29, 2018·Nanomaterials·Juan I BussioJosé Vicente González-Aramundiz
Jul 11, 2017·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (BIOHAZ)Rosina Girones
Jul 28, 2019·Journal of Pharmaceutical Sciences·Monika KauravRavi Shankar Pandey

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