Nanoparticulate silver. A new antimicrobial substance for bone cement

Der Orthopäde
Volker AltReinhard Schnettler

Abstract

Multiresistant bacteria have become an important problem in prosthetic joint infections. Their frequent resistance against gentamicin, which is commonly used in antibiotic-loaded bone cements, makes a new prophylaxis necessary. PMMA-cement was loaded with 1% nanoparticulate silver and its antibacterial activity tested in vitro against gentamicin-resistant MRSE and MRSA strains as well as being compared to the activity of plain and gentamicin-loaded bone cements. A quantitative elution testing was also done to study the potentially cytotoxic effects of NanoSilver cement. Unloaded and PMMA-cement loaded with 2% gentamicin did not exhibit any antibacterial activity against MRSE and MRSA. At 1%, NanoSilver cement completely inhibited the proliferation of MRSA and MRSE. NanoSilver bone cement did not show any significant differences compared to the non-toxic control group. If these promising in vitro results can be confirmed in vivo, NanoSilver bone cement may be of considerable value in total joint arthroplasty.

Citations

Jan 1, 1994·The Journal of Orthopaedic and Sports Physical Therapy·C A Smith
Jun 10, 2020·Drug Delivery and Translational Research·Magda FerreiraMaria Manuela Gaspar
Dec 15, 2005·The International Journal of Artificial Organs·C WagnerG M Hänsch

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