Nanopharmaceutics: Part II-Production Scales and Clinically Compliant Production Methods

Nanomaterials
Eliana B SoutoAntonello Santini

Abstract

Due the implementation of nanotechnologies in the pharmaceutical industry over the last few decades, new type of cutting-edge formulations-nanopharmaceutics-have been proposed. These comprise pharmaceutical products at the nanoscale, developed from different types of materials with the purpose to, e.g., overcome solubility problems of poorly water-soluble drugs, the pharmacokinetic and pharmacodynamic profiles of known drugs but also of new biomolecules, to modify the release profile of loaded compounds, or to decrease the risk of toxicity by providing site-specific delivery reducing the systemic distribution and thus adverse side effects. To succeed with the development of a nanopharmaceutical formulation, it is first necessary to analyze the type of drug which is to be encapsulated, select the type matrix to load it (e.g., polymers, lipids, polysaccharides, proteins, metals), followed by the production procedure. Together these elements have to be compatible with the administration route. To be launched onto the market, the selected production method has to be scaled-up, and quality assurance implemented for the product to reach clinical trials, during which in vivo performance is evaluated. Regulatory issues concerning nanop...Continue Reading

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Citations

Sep 16, 2020·Phytotherapy Research : PTR·Bahare SalehiRaffaele Pezzani
Mar 27, 2020·Foods·Alessandra DurazzoAntonello Santini
Jul 8, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Yiyee Mable SiawYen San Chan
Apr 5, 2020·Nanomaterials·Maria C TeixeiraEliana B Souto
Jun 19, 2021·International Journal of Pharmaceutics·Maria Camilla OpertiOya Tagit
Jun 20, 2021·Advanced Materials·Maryam ArabiLingxin Chen
Jul 3, 2021·Pharmaceutics·Sangeeta KumariLaurence Fitzhenry

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Methods Mentioned

BETA
nanoprecipitation

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