Nanoscale battery cathode materials induce DNA damage in bacteria.

Chemical Science
Tian A QiuChristy L Haynes

Abstract

The increasing use of nanoscale lithium nickel manganese cobalt oxide (Li x Ni y Mn z Co1-y-z O2, NMC) as a cathode material in lithium-ion batteries poses risk to the environment. Learning toxicity mechanisms on molecular levels is critical to promote proactive risk assessment of these complex nanomaterials and inform their sustainable development. We focused on DNA damage as a toxicity mechanism and profiled in depth chemical and biological changes linked to DNA damage in two environmentally relevant bacteria upon nano-NMC exposure. DNA damage occurred in both bacteria, characterized by double-strand breakage and increased levels of many putative chemical modifications on bacterial DNA bases related to direct oxidative stress and lipid peroxidation, measured by cutting-edge DNA adductomic techniques. Chemical probes indicated elevated intracellular reactive oxygen species and transition metal ions, in agreement with DNA adductomics and gene expression analysis. By integrating multi-dimensional datasets from chemical and biological measurements, we present rich mechanistic insights on nano-NMC-induced DNA damage in bacteria, providing targets for biomarkers in the risk assessment of reactive materials that may be extrapolated ...Continue Reading

References

Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D T BeranekF A Beland
Feb 1, 1982·The Science of the Total Environment·A R Stebbing
Feb 1, 1995·Mutation Research·D W FairbairnK L O'Neill
Apr 29, 1997·Mutation Research·A R CollinsR Stĕtina
Sep 10, 1999·The Journal of Biological Chemistry·K A JohnsonL J Marnett
Oct 20, 1999·Mutation Research·N P SinghH Lai
Dec 10, 1999·Microbiology and Molecular Biology Reviews : MMBR·A Kuzminov
Feb 17, 2001·Trends in Biotechnology·P J Pomposiello, B Demple
Mar 30, 2002·Critical Reviews in Oncology/hematology·Dimitrios Galaris, Angelos Evangelou
Feb 13, 2003·Current Opinion in Structural Biology·Wei Yang
Nov 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Laurie A VanderVeenLawrence J Marnett
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Daniel Agranoff, Sanjeev Krishna
Sep 1, 2005·PLoS Genetics·Eduardo P C RochaBénédicte Michel
Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Thomas EitingerJ Andrew C Smith
Mar 17, 2007·DNA Repair·Thomas HelledayBevin P Engelward
Apr 5, 2007·Nature Protocols·Peggy L Olive, Judit P Banáth
Nov 1, 2007·Chemical Research in Toxicology·Konstantin Salnikow, Anatoly Zhitkovich
Nov 24, 2007·Annual Review of Microbiology·Heidi H Hau, Jeffrey A Gralnick
Apr 27, 2010·Applied and Environmental Microbiology·David J SukovichLawrence P Wackett
Oct 22, 2010·Environmental and Molecular Mutagenesis·Nicklas Raun JacobsenHåkan Wallin
Dec 18, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·James A SwenbergThomas B Starr
Jun 23, 2011·BMC Bioinformatics·Lars-Henrik HeckmannJesper G Sørensen
Aug 25, 2011·Chemical Reviews·Huiyong YinNed A Porter
May 4, 2013·Environmental Science & Technology·Daniel Hsing Po KangOladele A Ogunseitan
Jan 21, 2014·Chemical Research in Toxicology·Silvia BalboPeter W Villalta
Jul 22, 2014·Environmental and Molecular Mutagenesis·Zdenka O KyjovskaUlla Vogel
Dec 10, 2014·Environmental and Molecular Mutagenesis·Hanna L KarlssonMaria Dusinska
Feb 11, 2015·Current Opinion in Microbiology·James A Imlay

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Methods Mentioned

BETA
electrophoresis
Fluorescence
fluorescence assay
PCR

Software Mentioned

R
Xcalibur Qual Browser
GeneInfo
Gene
NORMA
Vernier

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