Nanoscale biogenic iron oxides and neurodegenerative disease

FEBS Letters
Jon Dobson

Abstract

One of the characteristics of many neurodegenerative diseases is the disruption of normal iron homeostasis in the brain. Recent experimental work indicates that nanoscale magnetic biominerals (primarily magnetite and maghemite) may be associated with senile plaques and tau filaments found in brain tissue affected by these diseases. These findings have important implications for our understanding of the role of iron in neurodegenerative disease as well as profound implications for their causes. In addition, the presence of biogenic magnetite in affected tissue should also provide improved mechanisms for early detection through the modification of MRI pulse sequences.

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L KirschvinkB J Woodford
Aug 1, 1995·Journal of Neurochemistry·D A LoefflerP A LeWitt
Jan 1, 1995·Brain Research Bulletin·J R DunnB M Moskowitz
Mar 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C E SjøgrenC Johansson
Jun 1, 1993·Nutrition Reviews·J L BeardB C Jones
Jan 1, 1996·International Journal of Radiation Biology·B Brocklehurst, K A McLauchlan
Jul 31, 1996·Biochimica Et Biophysica Acta·P M Harrison, P Arosio
Dec 1, 1995·Journal of the Neurological Sciences·J R Connor, S L Menzies
Oct 1, 1996·Journal of the Neurological Sciences·F FazekasG Fazekas
Jan 1, 1997·Free Radical Biology & Medicine·W R Markesbery
Jan 1, 1997·Life Sciences·P FischerP Riederer
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Oct 1, 1998·Psychiatry Research·R V Parsey, K R Krishnan
Dec 4, 1998·Science·R E Dunin-BorkowskiP R Buseck
Jan 8, 1999·Biochimica Et Biophysica Acta·P P Schultheiss-GrassiJ Dobson
Jul 27, 1999·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·P P Schultheiss-Grassi, J Dobson
Feb 5, 2000·Biochimica Et Biophysica Acta·P D AllenK V Rao
Nov 23, 2000·Journal of Neuropathology and Experimental Neurology·A NunomuraM A Smith

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Citations

Jun 16, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Franziska BremJon Dobson
May 28, 2010·Journal of Materials Science. Materials in Medicine·Aparna MirSuprabha Nayar
Mar 10, 2004·Micron : the International Research and Review Journal for Microscopy·J M Cowley
Jun 27, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Michael G WallsYongxin Pan
Feb 24, 2010·Chemical Communications : Chem Comm·Chiung-Wen HsiehShuchen Hsieh
Sep 4, 2003·Proceedings. Biological Sciences·D HautotJ Dobson
Apr 2, 2005·Proceedings. Biological Sciences·Charles G CranfieldJon Dobson
Jul 20, 2006·Journal of the Royal Society, Interface·A MikhaylovaJ Dobson
Oct 4, 2006·Journal of the Royal Society, Interface·Franziska BremJon Dobson
Nov 26, 2008·Cephalalgia : an International Journal of Headache·M C KruitM D Ferrari
Apr 14, 2005·Nutrition Journal·Anna E O Fisher, Declan P Naughton
Jul 9, 2005·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
May 14, 2014·Progress in Neurobiology·Francesca A CupaioliLuigi Zecca
Mar 21, 2008·Ecotoxicology·Richard D HandyMark Crane
May 17, 2014·Current Opinion in Biotechnology·Sarah Stanley
Jul 12, 2014·Neurochemical Research·Charlotte PettersRalf Dringen
Feb 12, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ali DadrasFarzad Mokhtari
Oct 6, 2015·International Journal of Molecular Sciences·Niluka M DissanayakeSherine O Obare
Oct 10, 2009·Medical Hypotheses·Marcos Arturo Martínez BanaclochaHelios Martínez Banaclocha
Sep 17, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·H Sant'OvaiaA Rocha
Apr 24, 2004·Annals of the New York Academy of Sciences·Jon Dobson
Mar 27, 2012·BioFactors·Rudy J CastellaniXiongwei Zhu
Sep 20, 2012·Contrast Media & Molecular Imaging·Monika DezortovaMilan Hajek
Nov 24, 2004·Progress in Biophysics and Molecular Biology·John F Schenck
May 14, 2004·Journal of Magnetic Resonance·O C AlvesD M S Esquivel
Aug 22, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Martin KopániHedviga Mrazova
Jul 23, 2014·Biomatter·Daniele PasseriMarco Rossi
Aug 1, 2014·Frontiers in Aging Neuroscience·Nady BraidyPerminder Sachdev
Nov 7, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kausar B Riaz AhmedPeter L Goering
Dec 18, 2018·Applied Spectroscopy·Carolin HartmannNatalia P Ivleva
Feb 6, 2008·Small·Sharon SchreiberGunjan Agarwal
Jun 1, 2010·Advanced Materials·Robert LandsiedelWendel Wohlleben
Sep 24, 2005·NMR in Biomedicine·Yves GossuinJoanna Collingwood
Apr 6, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Samya BanerjeePeter J Sadler

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