Nanoscale investigation of human skin and study of skin penetration of Janus nanoparticles

International Journal of Pharmaceutics
Kamilia KemelCécile Laugel

Abstract

Janus nanoparticles (JNP) are innovative nanocarriers with an interesting pharmaceutical and cosmetic potential. They are characterized by the presence of a lipid compartment associated with an aqueous compartment delimited by a phospholipid bilayer containing phospholipids and non-ionic surfactants. The hydrodynamic diameter of JNP varies between 150 and 300 nm. The purpose of this study was to answer the following questions: after cutaneous application, are JNP penetrating? If so, how deep? And in which state, intact or degraded? It was essential to understand these phenomena in order to control the rate and kinetics of diffusion of active ingredients, which can be encapsulated in this vehicle for pharmaceutical or cosmetic purposes. An innovative technique called AFM-IR, was used to elucidate the behavior of JNP after cutaneous application. This instrument, coupling atomic force microscopy and IR spectroscopy, allowing to perform chemical analysis at the nanometer scale thanks to local absorption measurements. The identification of organic molecules at the nanoscale is possible without any labelling. Before cutaneous application of JNP, the nano-structure of untreated human skin was investigated with AFM-IR. Then, in vitro h...Continue Reading

References

Jan 10, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Nikiforos Kollias, Georgios N Stamatas
Apr 26, 2003·The Journal of Investigative Dermatology·Joke A BouwstraAdriaan C van Aelst
Sep 15, 2004·Journal of Structural Biology·Ashraf Al-AmoudiJacques Dubochet
May 30, 2006·Biochimica Et Biophysica Acta·Richard MendelsohnDavid J Moore
Dec 13, 2006·Analytical and Bioanalytical Chemistry·Guojin ZhangRichard Mendelsohn
Feb 27, 2008·Biochimica Et Biophysica Acta·Mila BonchevaValéry Normand
Oct 18, 2011·Journal of the American Academy of Dermatology·Caterina LongoGiovanni Pellacani
May 9, 2014·Expert Opinion on Drug Delivery·Le-Tuyet-Chau TranVincent Faivre
Jul 12, 2014·Applied Spectroscopy·Curtis MarcottGustavo S Luengo
Aug 27, 2014·Calcified Tissue International·Samuel Gourion-ArsiquaudAdele L Boskey
Mar 26, 2016·Mechanisms of Ageing and Development·Abigail K LangtonRachel Eb Watson
Dec 14, 2016·Chemical Reviews·Alexandre Dazzi, Craig B Prater
Jul 10, 2017·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·S Olsztyńska-JanusM A Czarnecki
May 4, 2018·Journal of Pharmaceutical Sciences·Kamilia KemelCécile Laugel
Jul 1, 2019·Journal of Pharmaceutical Sciences·Kamilia KemelCécile Laugel

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