Nanoscale iodized oil emulsion: a useful tracer for pretreatment sentinel node detection using CT lymphography in a normal canine gastric model.

Surgical Endoscopy
Joon Seok LimWoo Jin Hyung

Abstract

Pretreatment identification of the sentinel lymph nodes (SLNs) in gastric cancer patients may have great advantages for minimally invasive treatment. No reliable method for the detection of SLNs during the pretreatment period in gastric cancer has been established. The aim of this study was to determine whether computed tomographic (CT) lymphography using nanoscale iodized oil emulsion via endoscopic submucosal injection can visualize LNs. Five dogs underwent CT lymphography after endoscopic submucosal injection of 2 ml of a nanoscale iodized oil emulsion. CT images were taken before and 30, 90, and 210 min after contrast injection. Intraoperative SLN detection was performed using endoscopically injected indocyanine green lymphography for comparison. Computed tomographic lymphography with nanoscale iodized oil emulsion enabled the visualization of 19 enhanced LNs (mean = 3.8/dog, range = 3-6) with a 100% SLN detection rate. The locations of the SLNs were the lesser curvature (n = 7), greater curvature (n = 1), infrapyloric (n = 3), and left gastric (n = 8) areas. Contrast enhancement of SLNs continuously increased and peaked after 210 min at 142.4 ± 42.3 HU. No green LNs were visualized in the three locations that were detected...Continue Reading

References

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Citations

Sep 4, 2012·Annals of Surgical Oncology·Hiroya Takeuchi, Yuko Kitagawa
Apr 1, 2014·Gastrointestinal Endoscopy Clinics of North America·Mi-Young KimJoo Young Cho
Nov 22, 2012·Gastrointestinal Endoscopy Clinics of North America·Wataru Tamura, Norio Fukami
Apr 12, 2015·The Veterinary Journal·Tzu-Yin LinYuanpei Li
Oct 14, 2014·World Journal of Gastroenterology : WJG·Mi-Young KimJoo Young Cho
Sep 19, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Minoa K JungWoo Jin Hyung

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