Nanoscale Metal-Organic Framework Based Two-Photon Sensing Platform for Bioimaging in Live Tissue

Analytical Chemistry
Chan YangXiao-Bing Zhang

Abstract

Nanoscale metal-organic frameworks (NMOFs) have been applied for biomedical sensing in recent years. However, it is still a great challenge to construct a highly efficient NMOFs fluorescent probe for sensing in a biological system, with high signal-to-noise ratio, photostability, and deep tissue penetration. Herein, for the first time, we report the two-photon metal-organic framework (TP-MOF) as a sensing platform. The design of TP-MOF is based on NMOFs incorporating a target-responsive two-photon organic moiety through click chemistry. PCN-58, as a model building block, was covalently modified with a small-molecule probe for H2S or Zn2+ as model analytes. TP-MOF probes retain the fluorescence-responsive properties of the TP organic moiety and possess excellent photostability and selectivity, as well as biocompatibility. Benefiting from the near-infrared (∼820 nm) excited two-photon fluorophore, TP-MOF probes serve to sense and image their respective targets in live cells and tissue slices with a penetration of 130 μm. The molecular design presented here bodes well for the extension to other MOFs displaying sensing components for other analytes of interest.

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Citations

Jan 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaomeng ZhouLi Shang
Feb 7, 2020·Small·Jie Yang, Ying-Wei Yang
Apr 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xuan HuangJinjun Shao
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fatma Demir Duman, Ross S Forgan
Jun 15, 2021·Chemical Science·Eva Martínez-AhumadaIlich A Ibarra
Aug 27, 2021·ACS Applied Materials & Interfaces·Peng GaoBo Tang

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