Nanoscopic dynamics of phospholipid in unilamellar vesicles: effect of gel to fluid phase transition

The Journal of Physical Chemistry. B
V K SharmaV Urban

Abstract

The dynamics of phospholipids in unilamellar vesicles (ULVs) is of interest in biology, medical, and food sciences, since these molecules are widely used as biocompatible agents and a mimic of cell membrane systems. We have investigated the nanoscopic dynamics of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) phospholipid in ULVs as a function of temperature using elastic and quasielastic neutron scattering (QENS). The dependence of the signal on the scattering momentum transfer, which is a critical advantage of neutron scattering techniques, allows the detailed analysis of the lipid motions that cannot be carried out by other means. In agreement with a differential scanning calorimetry measurement, a sharp rise in the elastic scattering intensity below ca. 296 K indicates a phase transition from the high-temperature fluid phase to the low-temperature solid gel phase. The microscopic lipid dynamics exhibits qualitative differences between the solid gel phase (in a measurement at 280 K) and the fluid phase (in a measurement at a physiological temperature of 310 K). The analysis of the data demonstrates the presence of two types of distinct motions: the entire lipid molecule motion within a monolayer, also known as lateral di...Continue Reading

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Citations

Dec 18, 2015·The Journal of Physical Chemistry. B·Veerendra Kumar SharmaVolker S Urban
Apr 1, 2016·The Journal of Physical Chemistry. B·Subhankur MitraRamaprosad Mukhopadhyay
May 28, 2016·The Journal of Physical Chemistry Letters·V K SharmaV S Urban
May 10, 2016·Biochimica Et Biophysica Acta. General Subjects·H SetoT Yamada
Jan 7, 2017·Physical Chemistry Chemical Physics : PCCP·V K SharmaM Tyagi
Jul 13, 2018·Soft Matter·Hirsh NandaJoseph E Curtis
Feb 1, 2018·Scientific Reports·P S DubeyR Mukhopadhyay
Mar 10, 2018·Scientific Reports·Eugene Mamontov
Dec 10, 2015·Soft Matter·Matthew A BarrettThomas Hauß
Mar 20, 2018·Biophysics Reviews·V K Sharma, R Mukhopadhyay
Feb 20, 2019·Physical Review. E·Boris KheyfetsSergei Mukhin
Nov 2, 2019·Biochimica Et Biophysica Acta. Biomembranes·Karishma BakshiSajal Kumar Ghosh
Nov 2, 2019·Biochimica Et Biophysica Acta. Biomembranes·V K SharmaM Tyagi
Dec 18, 2020·Frontiers in Chemistry·Veerendra K SharmaR Mukhopadhyay
Mar 3, 2021·Biochimica Et Biophysica Acta. Biomembranes·Saheli MitraSajal Kumar Ghosh
Jun 6, 2017·Chemistry and Physics of Lipids·Lisa LautnerTobias Unruh
Aug 9, 2017·The Journal of Physical Chemistry. B·Takeshi YamadaHideki Seto
Dec 11, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Shuo QianLuke A Clifton
Feb 6, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Veerendra K Sharma, Shuo Qian
Feb 27, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Priya SinghSamir Kumar Pal
Feb 8, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Veerendra Kumar SharmaRamaprosad Mukhopadhyay
Oct 24, 2018·The Journal of Physical Chemistry. B·P S DubeyR Mukhopadhyay
Dec 4, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Jyotsna Bhatt MitraMukesh Kumar
Sep 7, 2021·The Journal of Physical Chemistry. B·Archita Maiti, Snehasis Daschakraborty

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