Nanosilk Increases the Strength of Diabetic Skin and Delivers CNP-miR146a to Improve Wound Healing.

Frontiers in Immunology
Stephen NiemiecCarlos Zgheib

Abstract

Diabetes mellitus is a metabolic disorder associated with properties and an increased risk of chronic wounds due to sustained pro-inflammatory response. We have previously of radical scavenging cerium oxide nanoparticles (CNP) conjugated to the anti-inflammatory microRNA (miR)-146a, termed CNP-miR146a, improves diabetic wound healing by synergistically lowering oxidative stress and inflammation, and we sought to evaluate this treatment in a topical application. Silk fibroin is a biocompatible polymer that can be fabricated into nanostructures, termed nanosilk. Nanosilk is characterized by a high strength-to-density ratio and an ability to exhibit strain hardening. We therefore hypothesized that nanosilk would strengthen the biomechanical properties of diabetic skin and that nanosilk solution could effectively deliver CNP-miR146a to improve diabetic wound healing. The ability of nanosilk to deliver CNP-miR146a to murine diabetic wounds and improve healing was assessed by the rate of wound closure and inflammatory gene expression, as well as histologic analysis. The effect of nanosilk on the properties of human diabetic skin was evaluated by testing the biomechanical properties following topical application of a 7% nanosilk solut...Continue Reading

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Citations

Mar 24, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Stephen M NiemiecKenneth W Liechty
Mar 28, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Wui Fang Chai, Kim San Tang
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Wenqian ZhangGuohui Liu

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Methods Mentioned

BETA
amputations
biopsy
electron diffraction

Software Mentioned

Bluehill
GraphPad Prism
NIS Elements – Advanced Research imaging
ImageJ
Kevlar

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