Nanosomal Amphotericin B is an efficacious alternative to Ambisome for fungal therapy

International Journal of Pharmaceutics
Saifuddin SheikhImran Ahmad

Abstract

Amphotericin B was formulated in lipids (Nanosomal Amphotericin B) without using any detergent or toxic organic solvents during the preparation. Electron microscopy and particle size determination of Nanosomal Amphotericin B showed a homogeneous population of nanosized particles below 100 nm. Hemolysis assay indicated that Nanosomal Amphotericin B causes significantly less lysis of red blood cells than Amphotericin B deoxycholate and was comparable to Ambisome. A maximum daily dose of Nanosomal Amphotericin B at 5 mg/kg in rabbits and 10 mg/kg in mice for 28 days showed no symptoms of toxicity, mortality or significant body weight reduction. Hematological and gross pathological analysis of tissues revealed no abnormalities attributable to the drug treatment. Nanosomal Amphotericin B and Ambisome were injected (iv) at 2 mg/kg consecutively for 5 days into mice infected with Aspergillus fumigatus. The treatment resulted in 90% survival with Nanosomal Amphotericin B and only 30% survival with Ambisome after 10 days of fungal infection. However, all of the 10 control mice which were not treated with Amphotericin B died within 5 days of fungal infection. Nanosomal Amphotericin B is safe, cost effective and provides an alternative op...Continue Reading

References

Apr 1, 1977·Antimicrobial Agents and Chemotherapy·F A AndrewsG A Sarosi
Oct 1, 1991·The Journal of Antimicrobial Chemotherapy·S L CroftE A Thornton
Nov 19, 1989·Molecular and Cellular Biochemistry·I AhmadB K Bachhawat
Jun 1, 1993·Journal of Clinical Pharmacy and Therapeutics·C Gates, R J Pinney
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luis Ostrosky-ZeichnerStuart H Cohen
Apr 24, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F Lanternier, O Lortholary

❮ Previous
Next ❯

Citations

Dec 19, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yuangang ZuKunlun Wang
Sep 1, 2015·International Journal of Pharmaceutics·Claudia Luengo-AlonsoPaolo Caliceti
Jul 8, 2014·International Journal of Pharmaceutics·Natassa PippaCostas Demetzos
Jul 31, 2012·International Journal of Pharmaceutics·Maha NasrAbdelbary Elhissi
Dec 3, 2014·Chemistry and Physics of Lipids·Moghis U AhmadImran Ahmad
Jun 21, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Congcong RanYe Jiang
Mar 3, 2018·Mycopathologia·Daniel Brustolin LudwigRubiana Mara Mainardes
Jan 8, 2020·Pharmaceutics·Célia Faustino, Lídia Pinheiro
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Brenda KischkelCarlos P Taborda
Apr 30, 2017·Molecular and Clinical Oncology·Radheshyam Naik, Mujtaba A Khan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.