Nanosphere Lithography on Fiber: Towards Engineered Lab-On-Fiber SERS Optrodes

Sensors
Giuseppe QueroAndrea Cusano

Abstract

In this paper we report on the engineering of repeatable surface enhanced Raman scattering (SERS) optical fiber sensor devices (optrodes), as realized through nanosphere lithography. The Lab-on-Fiber SERS optrode consists of polystyrene nanospheres in a close-packed arrays configuration covered by a thin film of gold on the optical fiber tip. The SERS surfaces were fabricated by using a nanosphere lithography approach that is already demonstrated as able to produce highly repeatable patterns on the fiber tip. In order to engineer and optimize the SERS probes, we first evaluated and compared the SERS performances in terms of Enhancement Factor (EF) pertaining to different patterns with different nanosphere diameters and gold thicknesses. To this aim, the EF of SERS surfaces with a pitch of 500, 750 and 1000 nm, and gold films of 20, 30 and 40 nm have been retrieved, adopting the SERS signal of a monolayer of biphenyl-4-thiol (BPT) as a reliable benchmark. The analysis allowed us to identify of the most promising SERS platform: for the samples with nanospheres diameter of 500 nm and gold thickness of 30 nm, we measured values of EF of 4 × 10⁵, which is comparable with state-of-the-art SERS EF achievable with highly performing col...Continue Reading

References

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Citations

May 16, 2019·Scientific Reports·Yuzhang LiangTing Xu
Apr 1, 2020·Nanoscale·Qi Wang, Lei Wang
Dec 15, 2018·Optics Letters·Karolina MilenkoDag R Hjelme
May 20, 2021·Chemistry, an Asian Journal·Mohammad Kamal HossainAmar Kamal Mohamedkhair
Jul 20, 2021·Analytical and Bioanalytical Chemistry·Simone BerneschiPaolo Matteini
Aug 29, 2019··Stefano ManagòFrancesco Galeotti

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Methods Mentioned

BETA
light scattering
surface enhanced Raman scattering
electron beam lithography

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