Nanospheres of doxorubicin as cross-linkers for a supramolecular hydrogelation

Scientific Reports
Qiang XueDan Ding

Abstract

In this study, we synthesized a peptide of Nap-GFFYGRGD, which could self-assemble into supramolecular nanofibers. The peptide itself could only form nanofibers but not hydrogels due to the relative weak inter-fiber interactions. The resulting nanofibers were then utilized as the vehicles for anticancer drug doxorubicin. It was found that the nanofibers of Nap-GFFYGRGD could not encapsulate doxorubicin, whereas the drug formed nanospheres, which were located at the surface of the nanofibers. Due to the electrostatic interactions between the negatively charged nanofibers and the positively charged doxorubicin nanospheres, the doxorubicin nanospheres were able to serve as a cross-linker to increase the inter-fiber interactions, leading to the formation of stable three-dimentional fiber networks and hydrogels. The resulting doxorubicin-peptide hydrogels were capable of releasing the drug in a sustained manner, which also showed comparable cytotoxicity as compared to free doxorubicin against a variety of cancer cell lines including HeLa and MCF-7 cancer cells. Therefore, this successful example using drug as the peptide nanofiber cross-linkers provided a new strategy for fabricating supramolecular hydrogelation for controlled deliv...Continue Reading

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Citations

Apr 12, 2016·Nano Today·Wang MaHonggang Cui
Sep 4, 2015·Chemical Communications : Chem Comm·Yang ShiLing Wang
Nov 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Faisal RazaLiang Ge
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Feb 10, 2021·Advanced Drug Delivery Reviews·Stéphane Bernhard, Mark W Tibbitt
Feb 8, 2018·ACS Applied Materials & Interfaces·Yingqiu QiGuangjun Nie
Jan 7, 2021·ACS Omega·Yuji Yamada

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Methods Mentioned

BETA
Transmission electron microscopy
rheology

Software Mentioned

Prism

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